An evaluation of HIV elite controller definitions within a large seroconverter cohort collaboration
| Autor: | Olson, Ad, Meyer, L, Prins, M, Thiebaut, R, Gurdasani, D, Guiguet, M, Chaix, Ml, Amornkul, P, Babiker, A, Sandhu, Ms, Porter, K, Giaquinto, Carlo, CASCADE Collaboration in EuroCoord |
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| Přispěvatelé: | University College of London [London] ( UCL ), Centre de recherche en épidémiologie et santé des populations ( CESP ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Université Paris-Sud - Paris 11 ( UP11 ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Public Health Service of Amsterdam, Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale ( INSERM ), The Wellcome Trust Sanger Institute [Cambridge], University of Cambridge [UK] ( CAM ), Epidémiologie, stratégies thérapeutiques et virologie cliniques dans l'infection à VIH, Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Infections à Vih, Réservoirs, Pharmacologie des Antirétroviraux et Prévention de la Transmission Mère Enfant, Université Paris Descartes - Paris 5 ( UPD5 ), International AIDS Vaccine Initiative [San Francisco] ( AVI ), HAL UPMC, Gestionnaire, University College of London [London] (UCL), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Cambridge [UK] (CAM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Descartes - Paris 5 (UPD5), International AIDS Vaccine Initiative [San Francisco] (AVI), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Medical Research Council Clinical Trials Unit ( MRC CTU ), Statistics In System biology and Translational Medicine ( SISTM ), Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National de Recherche en Informatique et en Automatique ( Inria ), Université Pierre et Marie Curie - Paris 6 ( UPMC ), Epidémiologie, stratégies thérapeutiques et virologie cliniques dans l'infection à VIH [Paris], Institut National de la Santé et de la Recherche Médicale ( INSERM ), Laboratoire de Virologie [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Necker - Enfants Malades [AP-HP], University of Texas Health Science Center, University of Texas at Houston [Houston] ( UTHealth ), Universitat de Barcelona, AII - Amsterdam institute for Infection and Immunity, APH - Amsterdam Public Health, Infectious diseases, Epidemiology and Data Science, Other departments, Experimental Immunology, Global Health |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Time Factors
Epidemiology Human immunodeficiency virus (HIV) lcsh:Medicine HIV Infections Communicable diseases medicine.disease_cause Men who have sex with men Cohort Studies 0302 clinical medicine [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases Antiretroviral Therapy Highly Active HIV Seropositivity Medicine 030212 general & internal medicine Cooperative Behavior lcsh:Science ComputingMilieux_MISCELLANEOUS 0303 health sciences Public health Multidisciplinary Statistics Hazard ratio Antiretrovirals HIV diagnosis and management [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie 3. Good health AIDS [ SDV.MHEP.MI ] Life Sciences [q-bio]/Human health and pathology/Infectious diseases HIV epidemiology Cohort [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases Infectious diseases RNA Viral HIV clinical manifestations Research Article Cohort study medicine.medical_specialty Clinical Research Design Sida Sexually Transmitted Diseases Viral diseases 03 medical and health sciences Acquired immunodeficiency syndrome (AIDS) Internal medicine VIH (Virus) Humans Retrospective Studies Demography Proportional Hazards Models 030304 developmental biology [ SDV ] Life Sciences [q-bio] business.industry Proportional hazards model HIV (Viruses) lcsh:R HIV Malalties infeccioses medicine.disease Clinical disease Salut pública Antiretroviral agents CD4 Lymphocyte Count [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie Immunology AIDS (Disease) lcsh:Q [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie business Mathematics Follow-Up Studies |
| Zdroj: | PLoS ONE PLoS ONE, Public Library of Science, 2014, 9 (1), pp.e86719. 〈10.1371/journal.pone.0086719〉 PLoS ONE, Public Library of Science, 2014, 9 (1), pp.e86719. ⟨10.1371/journal.pone.0086719⟩ PLoS ONE; Vol 9 Dipòsit Digital de la UB Universidad de Barcelona PLoS ONE, 2014, 9 (1), pp.e86719. ⟨10.1371/journal.pone.0086719⟩ Recercat. Dipósit de la Recerca de Catalunya instname PLoS ONE, 9(1). Public Library of Science PLoS ONE, Vol 9, Iss 1, p e86719 (2014) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0086719〉 |
| Popis: | for C A S C A D E Collaboration in EuroCoord; International audience; Background: Understanding the mechanisms underlying viral control is highly relevant to vaccine studies and elite control (EC) of HIV infection. Although numerous definitions of EC exist, it is not clear which, if any, best identify this rare phenotype.Methods: We assessed a number of EC definitions used in the literature using CASCADE data of 25,692 HIV seroconverters. We estimated proportions maintaining EC of total ART-naïve follow-up time, and disease progression, comparing to non-EC. We also examined HIV-RNA and CD4 values and CD4 slope during EC and beyond (while ART naïve).Results: Most definitions classify ∼1% as ECs with median HIV-RNA 43–903 copies/ml and median CD4>500 cells/mm3. Beyond EC status, median HIV-RNA levels remained low, although often detectable, and CD4 values high but with strong evidence of decline for all definitions. Median % ART-naïve time as EC was ≥92% although overlap between definitions was low. EC definitions with consecutive HIV-RNA measurements 90% of measurements |
| Databáze: | OpenAIRE |
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