A comparative study on chemical profile and biological activities of aerial parts (stems, flowers, leaves, pods and seeds) of Astragalus gombiformis
| Autor: | Kenza Kadi, Chawki Bensouici, Sabrina Lekmine, Kamel Nagaz, Samira Boussekine, Asma Kheddouma, A. I. Martín-García |
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| Přispěvatelé: | Ministry of Higher Education and Scientific Research (Algeria) |
| Rok vydání: | 2020 |
| Předmět: |
Naringenin
ABTS Antioxidant Acacetin Traditional medicine DPPH medicine.medical_treatment Biological activities Hyperoside Bioengineering Quinic acid LC-MSPhenolic compounds Applied Microbiology and Biotechnology Cirsilineol chemistry.chemical_compound chemistry medicine Astragalus gombiformis Agronomy and Crop Science Food Science Biotechnology |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | The present work aims to characterize the chemical profile of phenolic compounds and some biological activities of Astragalus gombiformis. The butanolic fractions of five aerial organs (stems, flowers, leaves, pods and seeds) were quantified and identified by LC–MS analysis. The results were revealed the presence of 13 phenolic compounds (quinic acid, p-coumaric acid, transfrulic acid, Hyperoside (quercetin-3-o-galactoside, Quercetrin (quercetin-3-o-rhamonoside), Apegenin-7-o-glucoside, kampherol, Naringenin, Apegenin, Luteolin, Cirsiliol, Cirsilineol and Acacetin. In terms of biological activities, the antioxidant,α-amylase inhibitory and anticholinesterase were determined. The butanolic extract from flowers showed the highest antioxidant activity in DPPH and ABTS(IC50: 16, 43 ± 0, 46 and 16, 13 ± 0, 35 μg/mL) very closer with standards tested and week activity with Galvinoxyl radical (GOR) (IC50: 583, 95 ± 2, 20 μg/mL), while other organ's extract exhibited moderate antioxidant activity. The leaves extract was found to exhibit the highest inhibitory effect against BChE (IC50: 165,54 ± 3,49 μg/mL) compared by the other parts which give a weak inhibitory effect at 200 μg/mL. A significant alpha-amylase inhibitory activity was displayed by seeds, leaves, pods and stems extracts (IC50:76.41 ± 3.72; 74.61 ± 3.68; 88.13 ± 1.81 and 83.81 ± 1.74 μg/mL) more the standard used. Based on these results, it is right to conclude that A. gombiformis is important source of the natural anti-diabetic, antioxidants and anti-Alzheimer′s disease. The authors are grateful to the Algerian Ministry of Higher Education and Scientific Research and the National Centre for Biotechnology Research (C.R.B.T) for their respective financial and material supports. |
| Databáze: | OpenAIRE |
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