Plasma Ropivacaine Levels During Awake Intracranial Surgery
| Autor: | Kevin J. Gingrich, Eugene R. Viscusi, David W. Andrews, Richard R. Bartkowski, Chuck Wilkerson, Paul B. Audu |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Chromatography Gas Local anesthetic toxicity Pilot Projects Neurosurgical Procedures Drug levels medicine Humans Ropivacaine Anesthetics Local Wakefulness Aged Scalp Dose-Response Relationship Drug business.industry Systemic absorption Middle Aged medicine.disease Amides Surgery Awake craniotomy Anesthesiology and Pain Medicine medicine.anatomical_structure Anesthesia Intracranial surgery Female Neurology (clinical) business Infiltration (medical) Anesthesia Local Half-Life medicine.drug |
| Zdroj: | Journal of Neurosurgical Anesthesiology. 17:153-155 |
| ISSN: | 0898-4921 |
| DOI: | 10.1097/01.ana.0000167446.56839.a4 |
| Popis: | Plasma ropivacaine levels produced by routine scalp infiltration for field block were assayed in eight patients undergoing awake intracranial surgery. Levels peaked within approximately 13 minutes, indicating rapid systemic absorption of ropivacaine. Potentially toxic plasma drug levels were achieved in three of eight patients, although no untoward effects attributable to elevated levels of ropivacaine were observed. Clinical vigilance is indicated during scalp infiltration with ropivacaine. |
| Databáze: | OpenAIRE |
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