Adverse reactions to propranolol in hospitalized medical patients: A report from the Boston Collaborative Drug Surveillance Program
| Autor: | David J. Greenblatt, Jan Koch-Weser |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Adult
Male Drug Heart block media_common.quotation_subject Blood Pressure Pulmonary Edema Propranolol Hyperthyroidism Angina Pectoris Angina Humans Medicine In patient Aged media_common business.industry Arrhythmias Cardiac Shock Middle Aged medicine.disease Pulmonary edema Evaluation Studies as Topic Shock (circulatory) Anesthesia Hypertension Female Azotemia Hypotension medicine.symptom Cardiology and Cardiovascular Medicine business Boston medicine.drug |
| Zdroj: | American Heart Journal. 86:478-484 |
| ISSN: | 0002-8703 |
| Popis: | Of 13,349 hospitalized medical patients monitored in a drug surveillance program, 268 (2.0 per cent) received propranolol during one or more hospitalizations. Angina and cardiac arrhythmias were the most common indications for therapy. Adverse reactions attributed to propranolol were reported in 25 patients (9.3 per cent). Eight reactions were considered life-threatening (pulmonary edema, shock, complete heart block); all of these involved depressed myocardial function, seven occurred in patients receiving 30 mg. per day or less, and four occurred within four hours after propranolol was first administered. Adverse reactions were more frequent in elderly patients, in those with azotemia or long hospital stays, and after intravenous administration. Propranolol dosage did not influence the frequency of adverse reactions. The findings suggest that in some patients serious adverse reactions occur rapidly even after small doses of propranolol, and that patients with more severe underlying disease may be predisposed to adverse reactions. |
| Databáze: | OpenAIRE |
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