Clinical implications of shared genetics and pathogenesis in autoimmune diseases
| Autor: | Cisca Wijmenga, Alexandra Zhernakova, Sebo Withoff |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Endocrinology
Diabetes and Metabolism NF-KAPPA-B Genome-wide association study VOLATILE ORGANIC-COMPOUNDS ADDISONS-DISEASE Coeliac disease Autoimmune Diseases Arthritis Rheumatoid 03 medical and health sciences 0302 clinical medicine Endocrinology Genetic predisposition Humans Lupus Erythematosus Systemic Medicine Genetic Predisposition to Disease JAPANESE POPULATION Hashimoto Disease SYSTEMIC-LUPUS-ERYTHEMATOSUS GENOME-WIDE ASSOCIATION 030304 developmental biology Autoimmune disease 0303 health sciences Lupus erythematosus business.industry Autoantibody CELIAC-DISEASE Microchimerism medicine.disease RHEUMATOID-ARTHRITIS 3. Good health 030220 oncology & carcinogenesis Immunology PSORIASIS SUSCEPTIBILITY LOCI business INFLAMMATORY-BOWEL-DISEASE |
| Zdroj: | Nature Reviews Endocrinology |
| ISSN: | 1759-5037 1759-5029 |
| DOI: | 10.1038/nrendo.2013.161 |
| Popis: | Many endocrine diseases, including type 1 diabetes mellitus, Graves disease, Addison disease and Hashimoto disease, originate as an autoimmune reaction that affects disease-specific target organs. These autoimmune diseases are characterized by the development of specific autoantibodies and by the presence of autoreactive T cells. They are caused by a complex genetic predisposition that is attributable to multiple genetic variants, each with a moderate-to-low effect size. Most of the genetic variants associated with a particular autoimmune endocrine disease are shared between other systemic and organ-specific autoimmune and inflammatory diseases, such as rheumatoid arthritis, coeliac disease, systemic lupus erythematosus and psoriasis. Here, we review the shared and specific genetic background of autoimmune diseases, summarize their treatment options and discuss how identifying the genetic and environmental factors that predispose patients to an autoimmune disease can help in the diagnosis and monitoring of patients, as well as the design of new treatments. |
| Databáze: | OpenAIRE |
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