Hormonal and seminal evaluation of Leydig cell tumour patients before and after orchiectomy
| Autor: | S. Zarrilli, L. Paesano, G. Lombardi, C. Di Somma, A. Colao, Vincenzo Mirone, M. De Rosa |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Urology Semen analysis Leydig cell tumour Follicle-stimulating hormone Endocrinology Testicular Neoplasms Semen Internal medicine medicine Humans Testosterone Orchiectomy Gonadal Steroid Hormones Estradiol medicine.diagnostic_test business.industry 17-alpha-Hydroxyprogesterone Androstenedione General Medicine Luteinizing Hormone medicine.disease Prolactin Leydig Cell Tumor Follicle Stimulating Hormone Luteinizing hormone business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Andrologia. 32:147-154 |
| ISSN: | 1439-0272 0303-4569 |
| Popis: | Seven patients (aged 25-38 years) were admitted because of mono- or bilateral gynaecomastia. Plasma levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, testosterone, 17-beta-estradiol, delta4-androstenedione, dehydropiandrosterone sulphate (DHEA-S) and 17-OH-progesterone were determined and semen analysis was carried out. FSH and LH levels were also measured after acute LH-RH administration (100 microg intravenously), and testosterone and 17-beta-estradiol were also evaluated after acute human chorionic gonadotrophin (hCG) administration (5000 IU intramuscularly). Testicular echography demonstrated the presence of a solid hypoechoic tumour. Therefore all patients were submitted to hemicastration by orchidofuniculotomy and a benign Leydig cell tumour was diagnosed in the removed testes. Hormonal and semen evaluations were repeated 3, 6, 9 and 12 months after surgery. The data before and after surgery were compared with a control group of 10 age-matched males. Before surgery, patients showed low FSH basal plasma levels; high levels of 17-beta-estradiol and low testosterone levels similar to those after hCG administration. A dyspermia was observed. Unilateral orchidectomy eliminated the autonomous secretion of oestrogen(s) so an increase of LH, FSH and testosterone levels, together with an improvement of spermatogenesis, were obtained. |
| Databáze: | OpenAIRE |
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