Hypercalcemic effect of insulin in the chick
| Autor: | Genaro M. A. Palmieri, Josephine Hawrylko, Abbie Hinton |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Male
medicine.medical_specialty Swine medicine.medical_treatment Parathyroid hormone Propranolol Endocrinology Species Specificity Suidae Internal medicine medicine Vitamin D and neurology Animals Insulin biology Chemistry biology.organism_classification medicine.disease Kinetics Hypoglycemic Effects Calcium Cattle Female Chickens Hypophosphatemia Hormone medicine.drug |
| Zdroj: | Endocrinology. 104(6) |
| ISSN: | 0013-7227 |
| Popis: | There are conflicting reports on the effect of insulin on plasma Ca concentration in rats. Low doses appear to decrease and higher doses to increase plasma Ca. Since birds are known to be very sensitive to parathyroid hormone and have resistance to the hypoglycemic effects of insulin, the effect of commercial and highly purified insulin on plasma Ca concentration was studied in 10-day-old chicks 60 min after the administration of the hormone. Both commerical bovine and purified porcine insulin provoked a dose-related elevation of plasma Ca. Although hypophosphatemia was observed with the highest dose of insulin used (0.4U), hypercalcemia was observed with 0.05 U insulin, a dose that did not modify plasma phosphate concentration. The slopes of the dose-response curves of insulin and parathyroid hormone were indistinguishable and different from that of 1 alpha-hydroxyvitamin D3. Neither propranolol nor deprivation of vitamin D altered the hypercalcemic response to insulin. Unexpectedly, propranolol (40 microgram/chick) provoked elevation of plasma Ca. It is concluded that insulin raises plasma Ca concentration in the chick by a mechanism(s) not yet elucidated. |
| Databáze: | OpenAIRE |
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