ADENOSINE ON MYOCARDIAL OXYGEN CONSUMPTION
| Autor: | David C. Warltier, G J Gross, Harold F. Hardman |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Chronotropic
Inotrope medicine.medical_specialty Adenosine Blood Pressure Dogs Oxygen Consumption Myocardial oxygen consumption Heart Rate Coronary Circulation Internal medicine Heart rate medicine Animals Pharmacology business.industry Myocardium Heart Blood flow Myocardial Contraction medicine.anatomical_structure Depression Chemical Anesthesia Cardiology business Perfusion Research Article medicine.drug Artery |
| Zdroj: | British Journal of Pharmacology. 57:409-412 |
| ISSN: | 0007-1188 |
| DOI: | 10.1111/j.1476-5381.1976.tb07681.x |
| Popis: | 1 A 3 min intracoronary infusion of adenosine (50 mug/min) produced a significant decrease in coronary artery perfusion pressure, left ventricular systolic pressure and myocardial O2 consumption in the isolated supported heart preparation of the dog perfused at a constant coronary blood flow. Heart rate was controlled at 150, 190 or 230 beats/minute. 2 Myocardial contractile force and maximal left ventricular dp/dt were not changed by adenosine infusion. 3 The absolute decrease in myocardial O2 consumption was greater at increasing heart rates whereas the decrease in coronary artery perfusion pressure and peak left ventricular systolic pressure were similar. 4 The results suggest that the reduction in myocardial O2 consumption produced by adenosine is not related to coronary vasodilatation or to a negative chronotropic or inotropic action, but may be due to a functional shunting of blood flow from high O2 extracting regions of the myocardium to low O2 extracting ones and/or important effects on myocardial substrate utilization. |
| Databáze: | OpenAIRE |
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