Peripherally Applied Synthetic Peptide isoAsp7-Aβ(1-42) Triggers Cerebral β-Amyloidosis
| Autor: | G. B. Telegin, Sergey A. Kozin, Philipp O. Tsvetkov, Andrey Lisitsa, Armen A. Ovsepyan, I. B. Cheglakov, Alexander A. Makarov |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Genetically modified mouse Gene isoform Pathology medicine.medical_specialty Neurology Molecular Sequence Data Mice Transgenic Plaque Amyloid Peptide Biology Toxicology Isoaspartate Mice Alzheimer Disease In vivo medicine Animals Amino Acid Sequence chemistry.chemical_classification Mice Inbred C3H Amyloid beta-Peptides Isoaspartic Acid General Neuroscience Amyloidosis P3 peptide Brain medicine.disease Peptide Fragments chemistry Injections Intravenous |
| Zdroj: | Neurotoxicity Research. 24:370-376 |
| ISSN: | 1476-3524 1029-8428 |
| Popis: | Intracerebral and intraperitoneal inoculation with β-amyloid-rich brain extracts originating from patients with Alzheimer's disease as well as intracerebral injection of aggregates composed of synthetic Aβ can induce cerebral β-amyloidosis, and associated cognitive dysfunctions in susceptible animal hosts. We have found that repetitive intravenous administration of 100 μg of synthetic peptide corresponding to isoAsp7-containing Aβ(1-42), an abundant age-dependent Aβ isoform present both in the pathological brain and in synthetic Aβ preparations, robustly accelerates formation of classic dense-core congophilic amyloid plaques in the brain of β-amyloid precursor protein transgenic mice. Our findings indicate this peptide as an inductive agent of cerebral β-amyloidosis in vivo. |
| Databáze: | OpenAIRE |
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