Synthesis of novel oxime-containing pyrazole derivatives and discovery of regulators for apoptosis and autophagy in A549 lung cancer cells
| Autor: | Jun Ding, Ying Li, Jun-Ying Miao, Liang-Wen Zheng, Hong-Shui Lv, Ying-Rui Liu, Di Ge, Bao-Xiang Zhao |
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| Rok vydání: | 2010 |
| Předmět: |
Lung Neoplasms
Stereochemistry Clinical Biochemistry Drug Evaluation Preclinical Molecular Conformation Pharmaceutical Science Antineoplastic Agents Apoptosis Pyrazole Crystallography X-Ray Biochemistry Chemical synthesis Structure-Activity Relationship chemistry.chemical_compound Cell Line Tumor Oximes Drug Discovery Autophagy Humans Cytotoxicity Molecular Biology A549 cell Chemistry Organic Chemistry Oxime Cell culture Pyrazoles Molecular Medicine |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 20:4766-4770 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2010.06.121 |
| Popis: | A series of novel oxime-containing pyrazole derivatives were synthesized by the reaction of ethyl 3-phenyl-1H-pyrazole-5-carboxylate derivatives and 2-bromo-1-phenylethanone followed by the reaction with hydroxylamine hydrochloride. The structures were determined by IR, 1H NMR, HRMS, and X-ray analysis. A dose- and time-dependent inhibition of proliferation was observed in A549 lung cancer cell after compound treatment. Inhibition of growth was mainly attributed to the autophagy induction. |
| Databáze: | OpenAIRE |
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