Muscarinic and nicotinic receptor modulation of object and spatial -back working memory in humans
| Autor: | Rodney J. Croft, Julia R. Ellis, Amity E. Green, Susan Ilic, Kathryn A. Ellis, Pradeep J. Nathan, Cali F. Bartholomeusz, K. Luan Phan |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Scopolamine Clinical Biochemistry Muscarinic Antagonists Nicotinic Antagonists Mecamylamine Neuropsychological Tests Receptors Nicotinic Toxicology Biochemistry Placebos Behavioral Neuroscience Cognition Double-Blind Method Muscarinic acetylcholine receptor medicine Muscarinic acetylcholine receptor M4 Humans Nicotinic Antagonist Prefrontal cortex Biological Psychiatry Pharmacology Analysis of Variance Working memory Reproducibility of Results Receptors Muscarinic Memory Short-Term Nicotinic agonist Cholinergic Female Psychology Neuroscience medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 81:575-584 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/j.pbb.2005.04.010 |
| Popis: | Working memory impairments in the n-back task in schizophrenia have been linked to sustained deficiency in mesocortical dopamine function. More recently, abnormalities in the cholinergic system have also been documented in schizophrenia, with cortical reductions in both nicotinic and muscarinic receptors. While the cholinergic hypothesis of memory is well established, the role of cholinergic receptors in modulating n-back working memory is not known. We investigated the effects of selective and simultaneous muscarinic and nicotinic antagonism on spatial and object n-back working memory performance. The study was a double-blind, placebo-controlled repeated-measures design in which 12 healthy subjects were tested under four acute treatment conditions; placebo (P), mecamylamine (M), scopolamine (S) and mecamylamine+scopolamine (MS). Muscarinic antagonism with scopolamine significantly impaired both object and spatial n-back working memory, whereas nicotinic antagonism with mecamylamine had little effect. Simultaneous antagonism of both muscarinic and nicotinic receptors produced greater impairments in both object and spatial n-back working memory performance than muscarinic or nicotinic antagonism alone. These results suggest that: (1) both muscarinic and nicotinic receptors may functionally interact to synergistically modulate n-back working memory, and (2) that n-back working memory impairments in schizophrenia may in part be due to reductions in both muscarinic and nicotinic receptors. |
| Databáze: | OpenAIRE |
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