MSCs from polytrauma patients: preliminary comparative study with MSCs from elective-surgery patients

Autor:	Gerardo J Martí-Chillón, Raul Perez Lopez, Javier González-Robledo, Fermín Sánchez-Guijo, Carmen da Casa, Juan F. Blanco, Silvia Preciado, David Pescador, Sandra Muntión
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Oncology medicine.medical_specialty Medicine (General) Population Cellular therapy Mesenchymal stromal cells Medicine (miscellaneous) QD415-436 Biochemistry Genetics and Molecular Biology (miscellaneous) Biochemistry Cell therapy MSC Immunophenotyping R5-920 Osteogenesis Internal medicine medicine Humans Elective surgery Bone regeneration education Cells Cultured Cell Proliferation education.field_of_study Multiple Trauma business.industry Research Mesenchymal stem cell Cell Differentiation Polytrauma Cell Biology medicine.disease Molecular Medicine Mesenchymal stem cells Stem cell business
Zdroj:	Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-11 (2021) Stem Cell Research & Therapy
ISSN:	1757-6512
Popis:	Background Polytrauma is a major clinical problem due to its impact on morbidity and mortality, especially among the younger population. Its pathophysiology is not completely elucidated, and the study of the involvement of certain cell populations with therapeutic potential, such as mesenchymal stromal cells (MSCs), is an area of growing interest, as mesenchymal cells have anti-inflammatory, immunoregulatory, and osteogenic potential. Methods In the present preliminary work, we have evaluated the characteristics of MSCs in terms of proliferation, immunophenotype, cell cycle, clonogenic capacity, and multilineage differentiation ability in a series of 18 patients with polytrauma and compared them to those from otherwise healthy patients undergoing elective spinal surgery. Results MSCs from polytrauma patients displayed higher proliferative potential with significantly higher cumulative population doublings, increased expression of some important cell adhesion molecules (CD105, CD166), and an early pre-osteogenic differentiation ability compared to those of the control group. Conclusions MSCs could potentially be of help in the repair process of polytrauma patients contribute to both cell-tissue repair and anti-inflammatory response. This potential should be further explored in larger studies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b23bb0ba2bf364e2558acda7b38eb83f https://doaj.org/article/030d0d1562ba44a9be680d16cf2b001f Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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