Carcinogenicity of metamifop, a novel herbicide, in Wistar rats following oral administration for 104 weeks
| Autor: | Woori Jo, Kyung Sung Kim, Hyun-Kyu Park, Hee-Kyung Gu, Woo-Chan Son, Sungwoong Jang, Bong Jin Chung, Jae-Eun Ryu, Hyun-Ji Choi |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Carcinogenicity Tests Administration Oral Biology Toxicology Mesothelial hyperplasia Pituitary adenoma Oral administration Internal medicine medicine Chronic Progressive Nephropathy Animals Humans Anilides Rats Wistar Benzoxazoles Dose-Response Relationship Drug Herbicides Mutagenicity Tests Body Weight Glomerulosclerosis General Medicine medicine.disease Rats Inbred F344 Rats Basophilia Endocrinology Carcinogens Adenocarcinoma Female Ovarian cancer |
| Zdroj: | Regulatory toxicology and pharmacology : RTP. 70(2) |
| ISSN: | 1096-0295 |
| Popis: | Metamifop is a novel herbicide with as yet undetermined properties. To assess its carcinogenicity, metamifop was mixed into standard rodent chow and fed to male and female Wistar rats at doses of 10, 100 and 750ppm for 104weeks. The viability/mortality of these rats was not affected by treatment with metamifop. Treatment had no significant effects on clinical parameters, and food consumption. Males and females fed 750ppm of metamifop for 104weeks showed decreases in body weight and body weight gain. Histopathological examination revealed that treatment with metamifop reduced non-neoplastic findings (chronic progressive nephropathy, tubular basophilia, tubular casts, glomerulosclerosis, basophilic and clear cell foci, senile atrophy, and mesothelial hyperplasia) and reduced neoplastic findings (thymoma, pituitary adenoma, and mammary fibroadenoma and adenocarcinoma in females, and mesenteric lymph node hemangioma in males) compared with control groups. Benign granulosa cell tumors were increased in a dose-dependent manner. As metamifop did not show any genotoxic potential, and there was no correlation between ovarian cancer and increased gonadal hormone levels in humans, the granulosa cell tumors observed in female rats fed a high dose of metamifop were considered not relevant to humans. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect