Effectiveness of Laparoscopic Total and Partial Fundoplication on Extraesophageal Manifestations of Gastroesophageal Reflux Disease
Autor: | Stavros A. Antoniou, Rudolph Pointner, Kai Uwe Asche, Oliver O. Koch, Frank A. Granderath, Adolf Kaindlstorfer |
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Rok vydání: | 2012 |
Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Fundoplication Nissen fundoplication Gastroenterology law.invention Randomized controlled trial law Surveys and Questionnaires Internal medicine Statistical significance medicine Humans Prospective Studies Prospective cohort study Aged Asthma business.industry Reflux Middle Aged medicine.disease Treatment Outcome Patient Satisfaction Cohort Gastroesophageal Reflux GERD Female Laparoscopy Surgery business Follow-Up Studies |
Zdroj: | Surgical Laparoscopy, Endoscopy & Percutaneous Techniques. 22:387-391 |
ISSN: | 1530-4515 |
Popis: | The aim of the present study was to evaluate the clinical effect of partial and total fundoplication on extraesophageal symptoms in a selected cohort of patients with gastroesophageal reflux disease (GERD). Hundred patients with documented GERD were randomized to either undergo floppy Nissen (n = 50) or Toupet fundoplication (n = 50). Symptom scores of cough, asthma, hoarseness, and distortion of taste were prospectively evaluated using a standardized symptom questionnaire before surgery and at 3- and 12-month follow-up. Statistical significance was set at a P-value of 0.05. All evaluated symptoms exhibited substantial improvement after Nissen fundoplication at 3- and 12-month follow-up. Similar therapeutic results were documented for Toupet fundoplication, although statistical significance could not be reached for asthma at long-term follow-up. In conclusion, the application of laparoscopic fundoplication is justified for patients with documented GERD and atypical symptoms refractory to medical treatment. Toupet fundoplication may have a lesser effect on asthma. |
Databáze: | OpenAIRE |
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