Effectiveness of Laparoscopic Total and Partial Fundoplication on Extraesophageal Manifestations of Gastroesophageal Reflux Disease

Autor: Stavros A. Antoniou, Rudolph Pointner, Kai Uwe Asche, Oliver O. Koch, Frank A. Granderath, Adolf Kaindlstorfer
Rok vydání: 2012
Předmět:
Zdroj: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques. 22:387-391
ISSN: 1530-4515
Popis: The aim of the present study was to evaluate the clinical effect of partial and total fundoplication on extraesophageal symptoms in a selected cohort of patients with gastroesophageal reflux disease (GERD). Hundred patients with documented GERD were randomized to either undergo floppy Nissen (n = 50) or Toupet fundoplication (n = 50). Symptom scores of cough, asthma, hoarseness, and distortion of taste were prospectively evaluated using a standardized symptom questionnaire before surgery and at 3- and 12-month follow-up. Statistical significance was set at a P-value of 0.05. All evaluated symptoms exhibited substantial improvement after Nissen fundoplication at 3- and 12-month follow-up. Similar therapeutic results were documented for Toupet fundoplication, although statistical significance could not be reached for asthma at long-term follow-up. In conclusion, the application of laparoscopic fundoplication is justified for patients with documented GERD and atypical symptoms refractory to medical treatment. Toupet fundoplication may have a lesser effect on asthma.
Databáze: OpenAIRE