Effects of dexmedetomidine on respiratory mechanics and control of breathing in normal rats
| Autor: | Débora S. Faffe, Patricia R. M. Rocco, Halina Cidrini Ferreira, Fátima Carneiro Fernandes, Giovanna Carvalho, Viviane Ramos Cagido, Walter A. Zin, Leonel dos Santos Pereira |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Physiology medicine.medical_treatment Respiratory physiology Animals Hypnotics and Sedatives Medicine Anesthesia Rats Wistar Respiratory system Dexmedetomidine Lung Pentobarbital Tidal volume Mechanical ventilation Diazepam business.industry Respiration General Neuroscience Respiration Artificial Rats Inhalation Respiratory Mechanics Breathing medicine.symptom business Adrenergic alpha-Agonists Hypercapnia Injections Intraperitoneal Respiratory minute volume medicine.drug |
| Zdroj: | Respiratory Physiology & Neurobiology. 154:342-350 |
| ISSN: | 1569-9048 |
| Popis: | Dexmedetomidine is a highly selective and specific alpha(2)-adrenergic agonist, with sedative, analgesic, and sympatholytic activities. The aim of the present study was to define the effects of DMED in respiratory mechanics in normal rats. In addition, lung morphometry was studied to determine whether the physiological changes reflected underlying morphological changes defining the sites of action of dexmedetomidine. Arterial blood gases were also determined. Twelve adult Wistar rats were randomly assigned to two groups of six animals each: PENTO and DMED. In PENTO group animals were sedated (diazepam, 5mg, i.p.) and anaesthetised with pentobarbital sodium (20mgkg(-1) i.p.). The rats of the DMED group received dexmedetomidine (250mugkg(-1) i.p. followed by intravenous infusion of 0.5mugkg(-1)h(-1)). In spontaneously breathing rats, minute ventilation, respiratory frequency, and neuromuscular inspiratory drive were lower in dexmedetomidine group, which also presented hypercapnia, whereas tidal volume, inspiratory, expiratory, and total respiratory cycle times were higher in dexmedetomidine group compared to the PENTO group. During mechanical ventilation, respiratory mechanical parameters were similar in both groups. These findings were supported by the absence of histological changes. In conclusion, under the conditions studied, dexmedetomidine did not change respiratory mechanical parameters and lung histology, but induced ventilatory depression. |
| Databáze: | OpenAIRE |
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