Physical function improvements with moderate or high-intensity exercise among older adults with or without HIV infection
| Autor: | Kristine M. Erlandson, Samantha MaWhinney, Todd T. Brown, Wendy M. Kohrt, Thomas B. Campbell, Sean A. McCandless, Lilyana Gross, Robert S. Schwartz, Catherine M. Jankowski, Melissa P Wilson |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Aging medicine.medical_specialty Immunology Human immunodeficiency virus (HIV) HIV Infections Physical function medicine.disease_cause Article 03 medical and health sciences 0302 clinical medicine Humans Immunology and Allergy Medicine Muscle Strength 030212 general & internal medicine Leg press Aged business.industry High intensity VO2 max Middle Aged 030112 virology Confidence interval Exercise Therapy Infectious Diseases Physical therapy Exercise intensity Female Sedentary Behavior business Serostatus |
| Zdroj: | AIDS. 32:2317-2326 |
| ISSN: | 0269-9370 |
| Popis: | OBJECTIVE Whether older people living with HIV (PLWH) can achieve similar functional benefits with exercise as their uninfected peers and the ideal intensity of exercise needed for these benefits are not known. DESIGN Sedentary adults (50-75 years) with or without HIV were recruited for 24 weeks of supervised endurance/resistance exercise. After 12 weeks of moderate-intensity exercise, participants were randomized to continue moderate-intensity or advance to high-intensity exercise for an additional 12 weeks. METHODS Outcomes by serostatus and exercise intensity (moderate, high) were compared using linear and mixed effects regression models and controlled for baseline values or week 12 values. RESULTS A total of 32 PLWH and 37 controls were enrolled; 27 PLWH (12 moderate/15 high) and 29 controls (15 moderate/14 high) completed 24 weeks. PLWH had significantly poorer physical function across nearly all baseline measures. Both groups had significant improvements in all functional measures. From 0 to 12 weeks, PLWH had significantly greater percentage improvements (mean, 95% confidence interval) than controls on VO2 max [5 (0, 10)%]; from 13 to 24 weeks, PLWH had significantly greater percentage improvements on stair climb [-5 (-10, -1)%], and the time to complete a 400-m walk [-3 (-5, -0)%]; all P less than 0.05. An interaction between exercise intensity and HIV serostatus was significant for measures of strength: PLWH randomized to high-intensity gained significantly more strength than moderate-intensity in bench and leg press [6 (0, 12)% and 10 (2, 17)% greater; both P |
| Databáze: | OpenAIRE |
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