Gonadotropins Induce the Release of Interleukin-1β, Interleukin-6 and Tumor Necrosis Factor-α from the Human Preovulatory Follicle
| Autor: | Bryan R. Hecht, J. Ricardo Loret de Mola, James M. Goldfarb, Miriam A. Friedlander, C. Jan Babbo, Gavin P. Baumgardner |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
medicine.medical_specialty medicine.drug_class Immunology Ovarian hyperstimulation syndrome Controlled ovarian hyperstimulation Biology Chorionic Gonadotropin Human chorionic gonadotropin Ovarian Follicle Ovulation Induction Internal medicine medicine Humans Immunology and Allergy Ovarian follicle Progesterone Estradiol Interleukin-6 Tumor Necrosis Factor-alpha Obstetrics and Gynecology Interleukin Luteinizing Hormone medicine.disease Follicular fluid Follicular Fluid medicine.anatomical_structure Endocrinology Follicular Phase Reproductive Medicine Female Gonadotropin Luteinizing hormone Gonadotropins Interleukin-1 |
| Zdroj: | American Journal of Reproductive Immunology. 39:387-390 |
| ISSN: | 1046-7408 |
| DOI: | 10.1111/j.1600-0897.1998.tb00374.x |
| Popis: | PROBLEM The effects of exogenous gonadotropin administration and steroid levels on the release of various cytokines into the human follicular fluid (FF) were studied. METHOD OF STUDY Forty patients were included in two groups, those undergoing controlled ovarian hyperstimulation (COH) (n = 33) and natural cycles (n = 7). FF transvaginal aspirations were performed 36 hr after administration of human chorionic gonadotropin or a spontaneous surge of luteinizing hormone, respectively. FF cytokine measurements were performed with sensitive immunoassays. RESULTS FF cytokine levels were higher after COH [interleukin (IL)-1 beta, 6.6 +/- 0.32 pg/ml; IL-6, 18.7 +/- 2.1 pg/ml; and tumor necrosis factor (TNF)-alpha, 32.5 +/- 4.9 pg/ml] than in natural unstimulated cycles (0.52 +/- 0.1 pg/ml, P < 0.001; 8.9 +/- 1.2 pg/ml, P < 0.01; and 13.2 +/- 2.6 pg/ml, P < 0.001, respectively). FF estradiol (E2) and progesterone levels were not statistically different between groups, despite the higher serum E2 levels observed in patients after COH. CONCLUSIONS Gonadotropins might regulate ovarian secretion of cytokines, because FF IL-1 beta, IL-6, and TNF-alpha levels after COH were higher than during natural cycles. |
| Databáze: | OpenAIRE |
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