1,2,4-Triazoloazine derivatives as a new type of herpes simplex virus inhibitors
| Autor: | A. N. Korovina, Inna L. Karpenko, T. S. Shestakova, Galegov Ga, V.L. Andronova, Vladimir L. Rusinov, Oleg N. Chupakhin, Anastasia L. Khandazhinskaya, Marina K. Kukhanova, Sergey L. Deev, Maxim V. Yasko, E. N. Ulomskii |
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| Rok vydání: | 2010 |
| Předmět: |
Models
Molecular Cell Survival DNA polymerase DNA-Directed DNA Polymerase Herpesvirus 1 Human Virus Replication medicine.disease_cause Antiviral Agents Biochemistry Cell Line Single-stranded binding protein chemistry.chemical_compound Polyphosphates Chlorocebus aethiops Drug Discovery medicine Animals Humans Vero Cells Molecular Biology Polymerase Nucleic Acid Synthesis Inhibitors biology DNA synthesis Triazines Organic Chemistry Herpes Simplex Triazoles Molecular biology Herpes simplex virus chemistry Viral replication biology.protein Nucleic acid DNA |
| Zdroj: | Bioorganic Chemistry. 38:265-270 |
| ISSN: | 0045-2068 |
| Popis: | A new class of inhibitors of herpes simplex virus replication was found. The compounds under study are derived from condensed 1,2,4-triazolo[5,1-c][1,2,4]triazines and 1,2,4-triazolo[1,5-a]pyrimidines, structural analogues of natural nucleic bases. Antiherpetic activity and cytotoxicity of the compounds were studied. The corresponding triphosphates of several active compounds were prepared and tested as inhibitors of DNA synthesis catalyzed by herpes simplex virus polymerase. The potential mechanism of their action is blocking of DNA dependent DNA polymerase, a key enzyme of viral replication. |
| Databáze: | OpenAIRE |
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