Resistive index of central retinal artery is a bioimaging biomarker for severity of diabetic retinopathy

Autor: Sandeep Saxena, Manila Khatri, Manoj Kumar, Ece Isin Akduman, Apjit Kaur Chabbra, Hang Pham, Shashi Kumar Bhasker, Levent Akduman
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: International Journal of Retina and Vitreous, Vol 5, Iss 1, Pp 1-8 (2019)
International Journal of Retina and Vitreous
ISSN: 2056-9920
DOI: 10.1186/s40942-019-0189-4
Popis: Background The present study was undertaken to assess the resistive index (RI) of central retinal artery (CRA) as a bioimaging biomarker for the severity of diabetic retinopathy (DR), for the first time. Methods Eighty-one consecutive patients of type 2 diabetes mellitus between the ages of 40 and 70 years were included in a tertiary care center-based cross sectional study. Severity of retinopathy was assessed according to Early Treatment Diabetic Retinopathy Study (ETDRS) classification: diabetes mellitus with no retinopathy (No DR) (n = 26); non-proliferative diabetic retinopathy (NPDR) (n = 29); and proliferative diabetic retinopathy (PDR) (n = 26). Twenty-six healthy controls of similar age were also included. Resistive index of CRA was studied using color Doppler and gray scale sonography. Central subfield thickness (CST), cube average thickness (CAT), retinal photoreceptor ellipsoid zone (EZ) disruption, and retinal nerve fiber layer (RNFL) thickness were evaluated using spectral domain optical coherence tomography. Sensitivity and specificity were assessed by receiver operating characteristic (ROC) curve. Results Mean RI of CRA for the study groups revealed significant increase with severity of diabetic retinopathy (F = 10.24, P Conclusions Resistive index of CRA is a reliable bioimaging biomarker for the severity of DR.
Databáze: OpenAIRE
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