Impact of Stress on Epilepsy: Focus on Neuroinflammation—A Mini Review
| Autor: | Claudia Espinosa-Garcia, Helena Zeleke, Asheebo Rojas |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Psychological intervention microglia Brain damage Comorbidity Review Epileptogenesis Catalysis neuroinflammation Inorganic Chemistry lcsh:Chemistry 03 medical and health sciences Epilepsy stress 0302 clinical medicine medicine Humans Chronic stress Physical and Theoretical Chemistry Intensive care medicine priming Molecular Biology lcsh:QH301-705.5 Spectroscopy Depression (differential diagnoses) seizures Inflammation Window of opportunity business.industry Organic Chemistry Stressor General Medicine medicine.disease NLRP3 inflammasome Computer Science Applications 030104 developmental biology psychiatric comorbidities in epilepsy lcsh:Biology (General) lcsh:QD1-999 depression Quality of Life epilepsy medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 4061, p 4061 (2021) |
| ISSN: | 1422-0067 |
| Popis: | Epilepsy, one of the most common neurological disorders worldwide, is characterized by recurrent seizures and subsequent brain damage. Despite strong evidence supporting a deleterious impact on seizure occurrence and outcome severity, stress is an overlooked component in people with epilepsy. With regard to stressor duration and timing, acute stress can be protective in epileptogenesis, while chronic stress often promotes seizure occurrence in epilepsy patients. Preclinical research suggests that chronic stress promotes neuroinflammation and leads to a depressive state. Depression is the most common psychiatric comorbidity in people with epilepsy, resulting in a poor quality of life. Here, we summarize studies investigating acute and chronic stress as a seizure trigger and an important factor that worsens epilepsy outcomes and psychiatric comorbidities. Mechanistic insight into the impact of stress on epilepsy may create a window of opportunity for future interventions targeting neuroinflammation-related disorders. |
| Databáze: | OpenAIRE |
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