Total synthesis of clavilactone B: a radical cyclization-fragmentation strategy
| Autor: | Hiroshi Suizu, Hiroshi Aoyama, Daisuke Shigeoka, Takehiko Yoshimitsu |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Samarium
biology Molecular Structure Stereochemistry Chemistry Organic Chemistry Molecular Conformation Total synthesis Clavilactone B Iodides Crystallography X-Ray Biochemistry Radical cyclization ErbB Receptors Lactones Cyclization Rapid access biology.protein Epidermal growth factor receptor Physical and Theoretical Chemistry Tyrosine kinase |
| Zdroj: | Organic letters. 17(1) |
| ISSN: | 1523-7052 |
| Popis: | A new synthetic route to clavilactone B, a naturally occurring inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, is disclosed. The route features a sequential samarium-mediated radical cyclization–fragmentation of an indanone derivative, which provides rapid access to a 10-membered carbocyclic motif fused to an aromatic ring. |
| Databáze: | OpenAIRE |
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