Mutations in the neurofibromatosis 1 gene in sporadic malignant melanoma cell lines
| Autor: | Nicholas C. Dracopoli, Thomas W. Glover, Francis S. Collins, Susan A. Tarlé, Lone B. Andersen, David H. Gutmann, Jane W. Fountain, David E. Housman |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities Transcription Genetic GTPase Biology medicine.disease_cause Genes Neurofibromatosis 1 Tumor Cells Cultured Genetics medicine Humans Genes Tumor Suppressor Neurofibromatosis Melanoma neoplasms Gene Mutation Messenger RNA Neurofibromin 1 Chromosome Mapping Proteins Neural crest DNA Neoplasm medicine.disease nervous system diseases Cancer research biology.protein Gene Deletion Chromosomes Human Pair 17 |
| Zdroj: | Nature Genetics. 3:118-121 |
| ISSN: | 1546-1718 1061-4036 |
| DOI: | 10.1038/ng0293-118 |
| Popis: | Neurofibromatosis type 1 (NF1) is a common autosomal dominant disorder characterized by progressive and variable involvement of tissues predominantly derived from the neural crest and a predisposition toward malignancies. The NF1 gene encodes neurofibromin, a GTPase-activating protein containing a GAP-related domain (NF1-GRD) that is capable of down-regulating ras by stimulating its intrinsic GTPase activity. We report a homozygous deletion of most of NF1 in one of eight malignant melanoma cell lines leading to loss of detectable mRNA and protein, as well as the apparent absence of protein and mRNA in another melanoma. This data suggests that NF1 can function as a tumour suppressor gene in the development or progression of malignant melanoma. |
| Databáze: | OpenAIRE |
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