Neurons in the guinea pig (Cavia porcellus) lateral lumbosacral spinal cord project to the central part of the lateral periaqueductal gray matter

Autor: Esther Marije Klop, Rutger Kuipers
Jazyk: angličtina
Rok vydání: 2006
Předmět:
media_common.quotation_subject
EXTERNAL URETHRAL SPHINCTER
PREGANGLIONIC NEURONS
Guinea Pigs
Central nervous system
Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
Cavia
Biology
Urination
Guinea pig
PONTINE MICTURITION CENTER
limbic system
Neural Pathways
medicine
spinomesencephalic
Animals
Periaqueductal Gray
ULTRASTRUCTURAL EVIDENCE
Molecular Biology
bladder
BARRINGTONS-NUCLEUS
micturition
media_common
Neurons
Brain Mapping
INHIBITORY BLADDER RESPONSES
IMMUNOREACTIVE NEURONS
General Neuroscience
LOWER URINARY-TRACT
SACRAL PARASYMPATHETIC NUCLEUS
Lumbosacral Region
HORSERADISH-PEROXIDASE
Anatomy
Spinal cord
biology.organism_classification
Retrograde tracing
visceroception
medicine.anatomical_structure
Spinal Cord
nervous system
Neurology (clinical)
Brainstem
Neuron
Neuroscience
Developmental Biology
Zdroj: Brain Research, 1101, 43-50. ELSEVIER SCIENCE BV
ISSN: 0006-8993
DOI: 10.1016/j.brainres.2006.05.039
Popis: In order to micturate successfully, information from the bladder has to be conveyed to the brainstem. In most experimental animals, this information is relayed, via the lumbosacral spinal cord, to the periaqueductal gray matter (PAG). Although the rat is the most used experimental animal in neurourological research, urodynamic studies show that guinea pig may be a better small experimental animal because its urodynamic profile is, in contrast to that of a rat, similar to that of humans. Therefore, the present study, using anterograde and retrograde tracing, was performed to determine whether the lumbosacral spinal cord projects to the PAG in guinea pig. Results show that neurons in the lateral part of the lumbosacral spinal cord project to the central parts of the PAG. This pathway may convey information about the level of bladder filling to the PAG.
Databáze: OpenAIRE
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