Mapping Complex Brain Torque Components and Their Genetic Architecture and Phenomic Associations in 24,112 Individuals
| Autor: | Arthur W. Toga, Lu Zhao, William Matloff, Yonggang Shi, Ryan P. Cabeen |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Brain Mapping Brain Cognition Biology Heritability Anthropometry Magnetic Resonance Imaging Article Genetic architecture Functional Laterality medicine.anatomical_structure Torque Evolutionary biology medicine Brain asymmetry Humans Phenomics Association (psychology) Set (psychology) Child Biological Psychiatry Neuroanatomy |
| Zdroj: | Biol Psychiatry |
| ISSN: | 1873-2402 |
| Popis: | Background The functional significance and mechanisms determining the development and individual variability of structural brain asymmetry remain unclear. Here, we systematically analyzed all relevant components of the most prominent structural asymmetry – brain torque (BT) and their relationships with potential genetic and nongenetic modifiers in a sample comprised 24,112 individuals from 6 cohorts. Methods BT features, including petalia, bending, dorso-ventral shift, brain tissue distribution asymmetries and cortical surface positional asymmetries, were directly modelled using a set of automatic 3D brain shape analysis approaches. Age, sex- and handedness-related effects on BT were assessed. The genetic architecture and phenomic associations of BT were investigated conducting genome- and phenome-wide association scans. Results Our results confirmed the population-level predominance of the typical anticlockwise torque and suggested a “first attenuating, then enlarging” dynamic across the lifespan (3-81 years) primarily for frontal, occipital and perisylvian BT features. Sex/handedness, BT and cognitive function of verbal-numerical reasoning were found to be interrelated statistically. We observed differential heritability of up to 56% for BT, especially in temporal language areas. Individual variations of BT were also associated with various phenotypic variables of neuroanatomy, cognition, lifestyle, sociodemographics, anthropometry, physical health, adult and child mental health. Our genomic analyses identified a number of genetic associations at lenient significance levels, which need to be further validated using larger samples in the future. Conclusions This study provides a comprehensive description of BT and insights into biological and other factors that may contribute to the development and individual variations of BT. |
| Databáze: | OpenAIRE |
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