Influence of pheniramine and chlorpheniramine on apomorphine induced compulsive gnawing in mice
Autor: | B. K. Bhattacharya, A. N. Dohadwalla, N. K. Dadkar |
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Rok vydání: | 1976 |
Předmět: |
Male
Chlorpheniramine Physostigmine Apomorphine Dopamine Tetrabenazine Mepyramine Methysergide Pharmacology Mice Parasympathetic Nervous System medicine Haloperidol Animals Humans Pyrilamine Behavior Animal P chlorophenylalanine Pheniramine Chemistry Drug Synergism Compulsive Behavior Female medicine.drug |
Zdroj: | Psychopharmacology. 48:7-10 |
ISSN: | 1432-2072 0033-3158 |
Popis: | In mice, apomorphine (10 mg/kg s.c.) does not induce a compulsion to gnaw, but pretreatment with antihistamines, viz. pheniramine, chlorpheniramine and mepyramine, in doses ranging from 30 to 60 mg/kg i.p. caused gnawing activity. Mepyramine showed significantly less effect when compared to the other two agents. Antihistamines are known to influence the activity of biogenic amines in central nervous system. The potentiation of apomorphine-induced gnawing by antihistamines might depend upon the reciprocal balance between dopaminergic and cholinergic systems. This was tested by blocking biosynthesis of biogenic amines or by blocking their receptors. The potentiation of gnawing was antagonised by physostigmine (0.25 mg/kg) or blocked by pretreatment with alpha-methyl-p-tyrosine (alpha-MPT) (4 X 150 mg/kg) and bis-(4-methyl-1-homopiperazinylthiocarbonyl)-disulphide (FLA) (40 mg/kg), while p-chlorophenyl alanine (p-CPA) (3 X 100 mg/kg) had no effect. Similarly, phenoxybenzamine (30 mg/kg) and haloperidol (1.0 mg/kg) inhibited gnawing activity, but methysergide (10 mg/kg) had no effect. Furthermore, pretreatment with tetrabenazine (20 mg/kg) and L-Dopa (200 mg/kg) did not affect gnawing activity. It is concluded that both pheniramine and chlorpheniramine potentiate apomorphine gnawing by upsetting the cholinergic and dopaminergic balance in favour of dopaminergic dominance. |
Databáze: | OpenAIRE |
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