Cancer Incidence Among Canadian Kidney Transplant Recipients
| Autor: | Ying Jiang, Stanley S. A. Fenton, Paul J. Villeneuve, Yang Mao, F. A. Shepherd, Douglas E. Schaubel |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Canada medicine.medical_specialty Adolescent Databases Factual medicine.medical_treatment Population Postoperative Complications Neoplasms Internal medicine Prevalence medicine Humans Immunology and Allergy Pharmacology (medical) Registries Renal replacement therapy Child education Kidney transplantation Aged Transplantation education.field_of_study business.industry Cancer Middle Aged medicine.disease Kidney Transplantation Survival Analysis Surgery Cancer registry Renal Replacement Therapy Kidney Failure Chronic Female business Kidney cancer Follow-Up Studies Kidney disease |
| Zdroj: | American Journal of Transplantation. 7:941-948 |
| ISSN: | 1600-6135 |
| DOI: | 10.1111/j.1600-6143.2007.01736.x |
| Popis: | A number of studies have observed increased cancer incidence rates among individuals who have received renal transplants. Generally, however, these studies have been limited by relatively small sample sizes, short follow-up intervals or focused on only one cancer site. We conducted a nationwide population-based study of 11,155 patients who underwent kidney transplantation between 1981 and 1998. Incident cancers were identified up to December 31, 1999, through record linkage to the Canadian Cancer Registry. Patterns of cancer incidence in the cohort were compared to the Canadian general population using standardized incidence ratios (SIRs). We examined variations in risk according time since transplantation, year of transplantation and age at transplantation. In our patient population, we observed a total of 778 incident cancers versus 313.2 expected (SIR = 2.5, 95% CI = 2.3-2.7). Site-specific SIRs were highest for cancer of the lip (SIR = 31.3, 95% CI = 23.5-40.8), non-Hodgkin's lymphoma (NHL) (SIR = 8.8, 95% CI = 7.4-10.5), and kidney cancer (SIR = 7.3, 95% CI = 5.7-9.2). SIRs for NHL and cancer of the lip and kidney were highest and among transplant patients. This study confirms previous findings of increased risks of posttransplant cancer. Our findings underscore the need for increased vigilance among kidney transplant recipients for cancers at sites where there are no population-based screening programs in place. |
| Databáze: | OpenAIRE |
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