Final Height and Its Predictive Factors after Renal Transplantation in Childhood
| Autor: | R C J W De Jong, S. M. P. F. De Muinck Keizer-Schrama, E. D. Wolff, M. A. J. de Ridder, Anita C. S. Hokken-Koelega, T. Stijnen, W Van Bergen, M A E Van Zaal, R. A. Donckerwolcke, Stenvert L. S. Drop |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male medicine.medical_specialty Percentile Adolescent medicine.drug_class medicine.medical_treatment Urology Predictive Value of Tests Prednisone medicine Humans Child Dialysis Retrospective Studies Cumulative dose business.industry Bone age Kidney Transplantation Body Height Surgery Transplantation Pediatrics Perinatology and Child Health Regression Analysis Corticosteroid Female Hemodialysis business medicine.drug |
| Zdroj: | Pediatric Research. 36:323-328 |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1203/00006450-199409000-00009 |
| Popis: | A retrospective study is reported assessing final height (FH) and its predictive factors in 52 patients (31 male, 21 female) who underwent renal transplantation (RTx) before the age of 15 y. They received prednisone daily or on alternate days as well as azathioprine. The study period covered 20 y. FH remained below the third height percentile [height standard deviation score for chronologic age (hSDSCA) < −1.88] for most of these patients (77% males, 71% females). Median (range) FH was 165.0 (143.0–176.8) cm in males and 153.0 (135.0–168.4) cm in females. Median difference between FH and target height was 15.0 and 15.4 cm for males and females, respectively. For both sexes, the median hSDSCA was already below −1.88 at the start of the first hemodialysis, after which it decreased significantly until the first RTx. After RTx, there was no significant improvement of hSDSCA. The predictive factors for FH were determined by evaluating various factors simultaneously in a multiple regression analysis. This analysis provided a regression equation for predicting FH. A higher hSDSCA at the time of the first RTx and alternate-day versus daily prednisone therapy both had a significantly positive influence on FH, whereas a longer duration of reduced GFR ( |
| Databáze: | OpenAIRE |
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