Glycopeptide in sputum from allergic asthma patients
| Autor: | Isoko Takazono, H. Masuda, Yukio Tanaka |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Endocrinology Diabetes and Metabolism Fractionation Biochemistry Glycosaminoglycan chemistry.chemical_compound Column chromatography Respiratory Hypersensitivity medicine Humans Aged Bronchiectasis Chemistry Glycopeptides Sputum Common cold Middle Aged medicine.disease Asthma Glycopeptide respiratory tract diseases Sialic acid Immunology Female medicine.symptom |
| Zdroj: | Biochemical Medicine and Metabolic Biology. 43:246-252 |
| ISSN: | 0885-4505 |
| DOI: | 10.1016/0885-4505(90)90031-u |
| Popis: | The glycopeptide and glycosaminoglycan content of sputa from allergic asthma, bronchiectasis, and common cold patients was assayed. The glycopeptide content was higher in sputum from allergic asthma patients than that in bronchiectasis and common cold patients, while no significant difference in the glycosaminoglycan content was detected among these materials. Fractionation of the glycopeptide by DEAE-cellulose column chromatography yielded four glycopeptide fractions at concentrations of 0.05 to 0.3 m NaCl from the allergic asthma samples, whereas it yielded three fractions at concentrations of 0.05 to 0.2 m NaCl from the bronchiectasis and common cold samples. They were characterized by increases in sialic acid and sulfate as the molarity of NaCl increased. Hexose was the main component and hexosamine was the next in each fraction from all materials. The increase in sputum glycopeptide in the allergic asthma samples was due to a large increase in sialic acid- and sulfate-rich glycopeptide. |
| Databáze: | OpenAIRE |
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