The association between c.1333C > T genetic polymorphism ofMTHFRgene and the risk of congenital heart diseases

Autor:	Jing Zhang, Bei Lv, Xia Li, Xian-yang Zhu, Qi-guang Wang
Rok vydání:	2014
Předmět:	Heart Defects Congenital Male medicine.medical_specialty Health Toxicology and Mutagenesis Clinical Biochemistry Population Polymorphism Single Nucleotide Biochemistry Gastroenterology Gene Frequency Risk Factors Internal medicine Genotype Humans Medicine Genetic Predisposition to Disease cardiovascular diseases Allele education Genetic Association Studies Methylenetetrahydrofolate Reductase (NADPH2) Genetics education.field_of_study biology business.industry Infant Odds ratio Confidence interval Increased risk Case-Control Studies Child Preschool Methylenetetrahydrofolate reductase biology.protein Female business Chd risk Polymorphism Restriction Fragment Length
Zdroj:	Biomarkers. 19:77-80
ISSN:	1366-5804 1354-750X
DOI:	10.3109/1354750x.2013.876099
Popis:	This study aims to evaluate the influence of methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms on congenital heart diseases (CHD) risk. The frequencies of allelic and genotypic in CHD patients were significantly different from non-CHD controls. Our data suggested that the c.1333C > T genetic polymorphism of MTHFR gene was statistically associated with the increased risk of CHD [TT versus CC: odds ratio (OR) = 2.70, 95% confidence interval (CI) 1.34–5.45, p = 0.005; T versus C: OR = 1.38, 95% CI 1.03–1.86, p = 0.032]. Our findings indicate that the c.1333C > T genetic polymorphism influences CHD risk in the studied population.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b22348ab7e2e4ab6345771f7df821860 https://doi.org/10.3109/1354750x.2013.876099 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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