Synthesis, characterization and biological activity studies of certain 1-((benzo[d]thiazol-2-yl) methyl)-4,5-dihydro-3-methyl-N-phenyl-1H-pyrazol-5-imine and 2-((5-aryl-1H-1,2,4-triazol-3-yl) methyl)benzo[d]thiazoles
| Autor: | Pathki Uma, P. K. Saiprakash, Kamatala Chinna Rajanna, Firasath Unnisa |
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| Rok vydání: | 2021 |
| Předmět: |
cyclization
010405 organic chemistry Chemistry Stereochemistry Aryl 2-(benzo[d]thiazol-2-yl) acetohydrazide Imine General Engineering Substituent chemistry.chemical_element biological activity Biological activity 2-((benzo[d]thiazol-2-1-((benzo[d]thiazol-2-yl)methyl)-3-methyl-1H-pyrazol-5(4H)-one 2-((5-aryl-1H-1 2 4-triazol-3-yl)methyl)benzo[d]thiazoles 010402 general chemistry 01 natural sciences 0104 chemical sciences lcsh:Chemistry condensation chemistry.chemical_compound 1-((benzo[d]thiazol-2-yl)methyl)-4 5-dihydro-3-methyl-N-phenyl-1H-pyrazol-5-imine lcsh:QD1-999 Chlorine lcsh:Q lcsh:Science |
| Zdroj: | Cogent Chemistry, Vol 3, Iss 1 (2017) |
| DOI: | 10.6084/m9.figshare.4807027.v3 |
| Popis: | In this work, 1-((benzo[d]thiazol-2-yl)methyl)-4,5-dihydro-3-methyl-N-phenyl-1H-pyrazol-5-imine (3a-h) have been successfully synthesized from the condensation of 2-((Benzo[d]thiazol-2-1-((benzo[d]thiazol-2-yl)methyl)-3-methyl-1H-pyrazol-5(4H)-one (2) with different aromatic amines. On the other hand, in another protocol, cyclization of 2-(benzo[d]thiazol-2-yl) acetohydrazide (4) with different aromatic aldehydes afforded 2-((5-aryl-1H-1,2,4-triazol-3-yl)methyl)benzo[d]thiazoles (5a-h). A perusal of the biological activity studies revealed that the derivatives having chlorine as substituent are more toxic to all six bacteria. Among the chloro group compounds, the compound which has methoxy group is more toxic. |
| Databáze: | OpenAIRE |
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