Routine treatment and outcome of breast cancer in younger versus elderly patients: results from the SENORA project of the prospective German TMK cohort study
Autor: | Andreas Köhler, Erik Engel, Mark-Oliver Zahn, Melanie Frank, Norbert Marschner, Thomas Fietz, Lisa Kruggel, Martina Jänicke |
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Rok vydání: | 2017 |
Předmět: |
Adult
Cancer Research medicine.medical_specialty Receptor ErbB-2 Epidemiology medicine.medical_treatment Breast Neoplasms Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Breast cancer Germany Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Tumour grading Humans Registries 030212 general & internal medicine Prospective cohort study Aged Proportional Hazards Models Aged 80 and over Chemotherapy business.industry Proportional hazards model Palliative Care Age Factors Middle Aged Prognosis medicine.disease Confidence interval Clinical trial Outcome assessment Treatment Outcome Receptors Estrogen Oncology Chemotherapy Adjuvant 030220 oncology & carcinogenesis Cohort studies Female Receptors Progesterone business Cohort study |
Zdroj: | Breast Cancer Research and Treatment |
ISSN: | 1573-7217 0167-6806 |
Popis: | Purpose There is an ongoing discussion about ‘undertreatment’ of breast cancer in elderly patients. Due to low accrual into clinical trials, level 1 evidence is scarce. We report prospective data of elderly patients with breast cancer treated by medical oncologists in Germany. Methods The SENORA project within the prospective cohort study TMK (Tumour Registry Breast Cancer) was conducted in 82 centres from 2007–2015. Among 2316 patients, half were enrolled with curative and half with palliative treatment intention. Overall, 478 patients (21%) were aged ≥ 70. Results In the adjuvant setting, elderly patients aged ≥ 70 had more advanced tumour stages at diagnosis and a higher prevalence of comorbidities than younger patients. Elderly patients received adjuvant chemotherapy less frequently, yet the 3-year disease-free survival was similar (86% vs. 88%). In the palliative setting, elderly patients more frequently received endocrine therapy and less frequently chemotherapy. Their median overall survival [24.9 months, 95% CI (confidence interval) 20.0–30.2] was significantly shorter than that of younger patients (39.7 months, 95% CI 34.9–44.2). A Cox proportional hazards model showed a significantly increased risk of mortality for: age ≥ 70 at start of therapy, negative HR- or HER2-status, higher number of metastatic sites, more comorbidities and high tumour grading at diagnosis. Conclusions Our results shed light on the routine treatment of elderly patients with breast cancer. A regression model demonstrated that age is but one of various prognostic factors determining the shorter overall survival of elderly patients. |
Databáze: | OpenAIRE |
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