Long-term leukopenia in a lung transplanted patient with cystic fibrosis treated with zoledronic acid: a case report
| Autor: | A. Karahasanovic, Anne-Luise Thorsteinsson, N. H. Bjarnason, Pia Eiken |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
medicine.medical_specialty Cystic Fibrosis Endocrinology Diabetes and Metabolism medicine.medical_treatment Osteoporosis 030209 endocrinology & metabolism Zoledronic Acid Cystic fibrosis Gastroenterology Organ transplantation 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Lung transplantation 030212 general & internal medicine Leukopenia Bone Density Conservation Agents Diphosphonates business.industry Imidazoles Bisphosphonate medicine.disease Surgery Zoledronic acid Respiratory failure Female medicine.symptom business Lung Transplantation medicine.drug |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1433-2965 0937-941X |
| DOI: | 10.1007/s00198-016-3559-x |
| Popis: | Cystic fibrosis (CF) is a serious autosomal recessive genetic disorder associated with chronic lung disease, malabsorption, malnutrition, pancreatic insufficiency and premature respiratory failure. Recent advances in medical science and technology have increased the lifespan of patients with CF, albeit with long-term consequences of the disease, such as osteoporosis, becoming of increasing significance. The medical treatment of osteoporosis in patients with CF or after organ transplantation is still being explored, and no clear guidelines regarding the best choice of bisphosphonate exist. We report a case of a young woman with CF, lung transplantation and low bone mass developing long-term leukopenia after treatment with zoledronic acid. The leukopenia, with a strong affection of the neutrocytes, lasted for 4 months and the condition only went into remission after granulocyte-colony stimulating factor (G-CSF) treatment. It is important to be aware of symptomatic leukopenia in immunosuppressive patients after treatment with zoledronic acid. |
| Databáze: | OpenAIRE |
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