Platelet MAO activity and the 5-HTT gene promoter polymorphism are associated with impulsivity and cognitive style in visual information processing
| Autor: | Jüri Parik, Marika Paaver, Jaanus Harro, Niklas Nordquist, Maarike Harro, Lars Oreland |
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| Rok vydání: | 2007 |
| Předmět: |
Blood Platelets
Male Adolescent Genotype Impulsivity Serotonergic chemistry.chemical_compound Cognition Mental Processes Reaction Time medicine Humans Visual Pathways Allele Promoter Regions Genetic Neurotransmitter Monoamine Oxidase Gene Alleles Serotonin transporter Serotonin Plasma Membrane Transport Proteins Pharmacology Genetics Psychological Tests Polymorphism Genetic biology Promoter Pattern Recognition Visual chemistry Impulsive Behavior Visual Perception biology.protein Female Serotonin medicine.symptom Psychology |
| Zdroj: | Psychopharmacology. 194:545-554 |
| ISSN: | 1432-2072 0033-3158 |
| DOI: | 10.1007/s00213-007-0867-z |
| Popis: | Low capacity of the central serotonergic system has been associated with impulsive behaviour. Both low platelet monoamine oxidase (MAO) activity and the short (S) allele of the serotonin transporter gene promoter region polymorphism (5-HTTLPR) are proposed to be markers of less efficient serotonergic functioning.The effect of the two markers for serotonin system efficiency on performance in a visual comparison task (VCT) and self-reported impulsiveness (Barratt Impulsiveness Scale, BIS-11) were investigated in healthy adolescents participating in the Estonian Children Personality Behaviour and Health Study. Possible confounding effect of general cognitive abilities on the performance in VCT was controlled for.Low platelet MAO activity and carrying of the S allele of 5-HTTLPR were both associated with higher error-rate and more impulsive performance in VCT. Platelet MAO activity and 5-HTTLPR S allele had a significant interactive effect on self-reported impulsivity (BIS-11). The effect of platelet MAO activity on both self-reported and performance impulsivity was significant only in the S allele carriers. The effect of 5-HTTLPR S allele on impulsive performance remained significant after controlling for general cognitive abilities.The two markers of lower serotonergic capacity, 5-HTTLPR S allele and low platelet MAO activity, have a similar and partly synergistic influence on self-reported as well as performance measures of impulsivity. |
| Databáze: | OpenAIRE |
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