Theranostics in Interventional Oncology: Versatile Carriers for Diagnosis and Targeted Image-Guided Minimally Invasive Procedures
| Autor: | Niklaus Schaefer, Antonia Digklia, Nils Degrauwe, Rafael Duran, Arnaud Hocquelet, Alban Denys |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
radioembolization interventional oncology medicine.medical_specialty theranostics Interventional oncology Patient characteristics Review transarterial chemoembolization HCC - Hepatocellular carcinoma ablation 03 medical and health sciences 0302 clinical medicine Molecular level Medical imaging medicine cancer Medical physics SIRT Pharmacology (medical) HCC Minimally invasive procedures Pharmacology business.industry Selective internal radiation therapy lcsh:RM1-950 Clinical Practice 030104 developmental biology lcsh:Therapeutics. Pharmacology 030220 oncology & carcinogenesis business |
| Zdroj: | Frontiers in Pharmacology, Vol 10 (2019) Frontiers in Pharmacology |
| ISSN: | 1663-9812 |
| DOI: | 10.3389/fphar.2019.00450 |
| Popis: | We are continuously progressing in our understanding of cancer and other diseases and learned how they can be heterogeneous among patients. Therefore, there is an increasing need for accurate characterization of diseases at the molecular level. In parallel, medical imaging and image-guided therapies are rapidly developing fields with new interventions and procedures entering constantly in clinical practice. Theranostics, a relatively new branch of medicine, refers to procedures combining diagnosis and treatment, often based on patient and disease-specific features or molecular markers. Interventional oncology which is at the convergence point of diagnosis and treatment employs several methods related to theranostics to provide minimally invasive procedures tailored to the patient characteristics. The aim is to develop more personalized procedures able to identify cancer cells, selectively reach and treat them, and to assess drug delivery and uptake in real-time in order to perform adjustments in the treatment being delivered based on obtained procedure feedback and ultimately predict response. Here, we review several interventional oncology procedures referring to the field of theranostics, and describe innovative methods that are under development as well as future directions in the field. |
| Databáze: | OpenAIRE |
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