Serum adiponectin in women with polycystic ovarian syndrome and its relation to clinical, metabolic and endocrine parameters
| Autor: | Mariusz Nowak, Dariusz Kajdaniuk, Joanna Głogowska-Szelag, Bogdan Marek, Beata Kos-Kudła, Danuta Niedziołka, Lucyna Siemińska |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Blood Glucose medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism Body Mass Index Impaired glucose tolerance Endocrinology Waist–hip ratio Insulin resistance Sex hormone-binding globulin Risk Factors Internal medicine medicine Humans Gonadal Steroid Hormones Glucose tolerance test medicine.diagnostic_test Adiponectin biology Free androgen index business.industry Waist-Hip Ratio Complement C1q nutritional and metabolic diseases Glucose Tolerance Test medicine.disease Cardiovascular Diseases Case-Control Studies biology.protein Intercellular Signaling Peptides and Proteins Regression Analysis Female Collagen business Body mass index hormones hormone substitutes and hormone antagonists Polycystic Ovary Syndrome |
| Zdroj: | Journal of endocrinological investigation. 27(6) |
| ISSN: | 0391-4097 |
| Popis: | Several studies have demonstrated that low levels of serum adiponectin are present in obesity, insulin resistance, hypertension and hyperlipidemias. The aim of our study was to determine whether serum adiponectin level is different between patients with polycystic ovarian syndrome (PCOS) and control subjects. We also investigated relationships between various cardiovascular risk factors, levels of serum adiponectin and other hormones, such as androstendione, testosterone, estradiol, DHEAS, sex hormone binding globulin (SHBG), and leptin. We also analysed the correlation between serum adiponectin and free androgen index. Ninety-one women with clinical diagnosed PCOS and 53 healthy control subjects, carefully matched by body mass index (BMI) and age, were enrolled in the study. The fasting blood samples were obtained and all participants underwent an oral 75 g glucose tolerance test. The prevalences of impaired glucose tolerance (IGT), hypertension and hypertriglyceridemia were higher in the PCOS group. PCOS women had increased androgen concentrations and higher free androgen index and decreased level of serum SHBG. Lower serum adiponectin concentrations were observed among cases than in controls (median 13.7 μg/ml vs 17.8 μg/ml, p |
| Databáze: | OpenAIRE |
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