Vitamin D and barrier function: a novel role for extra-renal 1 alpha-hydroxylase
| Autor: | Martin Hewison, Ronjon Chakraverty, John S. Adams, Daniel Zehnder |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Calcium metabolism
25-Hydroxyvitamin D3 1-alpha-Hydroxylase medicine.medical_specialty 25-Hydroxyvitamin D3 1-alpha-hydroxylase Biology medicine.disease Kidney Biochemistry vitamin D deficiency Bone remodeling Secosteroid chemistry.chemical_compound Endocrinology chemistry Calcitriol Psoriasis Internal medicine medicine Vitamin D and neurology Animals Humans Vitamin D Molecular Biology Protein kinase C |
| Zdroj: | Molecular and cellular endocrinology. 215(1-2) |
| ISSN: | 0303-7207 |
| Popis: | Much recent attention has focused on the positive health benefits of vitamin D beyond its established role in calcium homeostasis. Epidemiology has highlighted the link between vitamin D deficiency and prevalent diseases such as common cancers and autoimmune disease. Furthermore, studies in vitro have shown that the active form of vitamin D, 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) is a potent antiproliferative and immunosuppressive agent. The net effect of this has been the generation and analysis of synthetic analogues of vitamin D for potential use in the treatment of cancers and other disorders including psoriasis. However, there is increasing interest in the impact that vitamin D may have on normal physiology above and beyond its classical effects on calcium homeostasis and bone metabolism. We have postulated that these 'non-calcemic' effects of vitamin D are dependent on extra-renal synthesis of 1,25(OH)(2)D(3) via the enzyme 1 alpha-hydroxylase at barrier sites throughout the body. Here we present a review of the mechanisms associated with extra-renal 1 alpha-hydroxylase, and we also speculate on how this 'new' physiological role for vitamin D may actually reflect an ancient function for this pluripotent secosteroid. |
| Databáze: | OpenAIRE |
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