Unravelling myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) : Gender-specific changes in the microRNA expression profiling in ME/CFS

Autor: Amanpreet K. Cheema, Fanny Collado, Lubov Nathanson, Jesús Castro-Marrero, Elisa Oltra, Nancy G. Klimas, Leonor Sarria, Eva Martín-Martínez, Mary A Fletcher, José Alegre, Mina Bekheit, Eloy Almenar-Pérez
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Metabolic state
Male
musculoskeletal diseases
Time Factors
peripheral blood mononuclear cell
Encephalomyelitis
myalgic encephalomyelitis/chronic fatigue syndrome
Inflammation
Immune function
Immune system
microRNA
Chronic fatigue syndrome
gender
Medicine
Humans
Exercise
immune function
Sex Characteristics
Fatigue Syndrome
Chronic
exercise
business.industry
Gene Expression Profiling
virus diseases
Gender
Nutritional status
Cell Biology
Fasting
Original Articles
Middle Aged
Peripheral blood mononuclear cell
medicine.disease
microRNAs
nervous system diseases
Gene expression profiling
MicroRNAs
Gene Expression Regulation
Myalgic encephalomyelitis/chronic fatigue syndrome
inflammation
Case-Control Studies
Immunology
Molecular Medicine
Female
Original Article
medicine.symptom
business
human activities
Zdroj: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Journal of Cellular and Molecular Medicine
Popis: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multisystem illness characterized by medically unexplained debilitating fatigue with suggested altered immunological state. Our study aimed to explore peripheral blood mononuclear cells (PBMCs) for microRNAs (miRNAs) expression in ME/CFS subjects under an exercise challenge. The findings highlight the immune response and inflammation links to differential miRNA expression in ME/CFS. The present study is particularly important in being the first to uncover the differences that exist in miRNA expression patterns in males and females with ME/CFS in response to exercise. This provides new evidence for the understanding of differential miRNA expression patterns and post‐exertional malaise in ME/CFS. We also report miRNA expression pattern differences associating with the nutritional status in individuals with ME/CFS, highlighting the effect of subjects' metabolic state on molecular changes to be considered in clinical research within the NINDS/CDC ME/CFS Common Data Elements. The identification of gender‐based miRNAs importantly provides new insights into gender‐specific ME/CFS susceptibility and demands exploration of sex‐suited ME/CFS therapeutics.
Databáze: OpenAIRE
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