Adrenalectomy alters the sensitivity of the central nervous system melanocortin system
| Autor: | Drazen, DL, Wortman, MD, Schwartz, MW, Clegg, DJ, van Dijk, G, Woods, SC, Seeley, RJ, Drazen, Deborah L., Wortman, Matthew D., Schwartz, Michael W., Woods, Stephen C., Seeley, Randy J. |
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| Přispěvatelé: | University of Groningen, Van Dijk lab |
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Central Nervous System
Leptin Male medicine.medical_specialty FOOD-INTAKE Endocrinology Diabetes and Metabolism medicine.medical_treatment Appetite Biology OB/OB MICE ALPHA-MSH RAT-BRAIN Peptides Cyclic AGOUTI-RELATED PROTEIN Eating Melanocortin receptor NEUROENDOCRINE Orexigenic Internal medicine Internal Medicine medicine Animals Rats Long-Evans ACTH receptor OBESE GENE GLUCOCORTICOID RECEPTOR-IMMUNOREACTIVITY Glucocorticoids Injections Intraventricular Third Ventricle Dose-Response Relationship Drug Receptors Melanocortin Adrenalectomy digestive oral and skin physiology LEPTIN LEVELS Proteins Melanotan II Rats Endocrinology BODY-WEIGHT Intercellular Signaling Peptides and Proteins Receptor Melanocortin Type 4 Melanocortin Corticosterone Glucocorticoid hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Diabetes, 52(12), 2928-2934. AMER DIABETES ASSOC |
| ISSN: | 0012-1797 |
| Popis: | Removal of adrenal steroids by adrenalectomy (ADX) reduces food intake and body weight in rodents and prevents excessive weight gain in many genetic and dietary models of obesity. Thus, glucocorticoids appear to play a key role to promote positive energy balance in normal and pathological conditions. By comparison, central nervous system melanocortin signaling provides critical inhibitory tone to regulate energy balance. The present experiments sought to test whether glucocorticoids influence energy balance by altering the sensitivity to melanocortin receptor ligands. Because melanocortin-producing neurons are hypothesized to be downstream of leptin in a key weight-reducing circuit, we tested rats for their sensitivity to leptin and confirmed reports that the hypophagic response to third ventricular (i3vt) leptin is increased in ADX rats and is normalized by glucocorticoid replacement. Next we tested rats for their sensitivity to the melanocortin agonist melanotan II and found that, as for leptin, ADX enhanced the hypophagic response via a glucocorticoid-dependent mechanism. The central nervous system melanocortin system is unique in that it includes the endogenous melanocortin receptor antagonist, AgRP. The orexigenic effect of i3vt AgRP was absent in ADX rats and restored by glucocorticoid replacement. We conclude that the potent weight-reducing effects of ADX likely involve heightened responsiveness to melanocortin receptor stimulation. |
| Databáze: | OpenAIRE |
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