Multicentric Reticulohistiocytosis: A Case Report of an Atypical Presentation in a 2-Year-Old
| Autor: | Julianne A. Mann, Jeremy Bauer, Jaleh Olson, Victoria W. Cartwright M.D., Kevin White, M.P.H. Dawn Nolt M.D. |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Histiocytosis Non-Langerhans-Cell Biopsy Arthritis Dermatology Diagnosis Differential medicine Humans Granuloma annulare medicine.diagnostic_test business.industry Infant Polyarticular Arthritis Multicentric reticulohistiocytosis medicine.disease Infliximab Surgery Histiocytosis medicine.anatomical_structure Pediatrics Perinatology and Child Health Skin biopsy Forehead Female Dermatologic Agents business |
| Zdroj: | Pediatric Dermatology. 32:e70-e73 |
| ISSN: | 0736-8046 |
| DOI: | 10.1111/pde.12531 |
| Popis: | Multicentric reticulohistiocytosis (MRH) is a rare systemic inflammatory granulomatous disease marked by severe and often rapidly progressive polyarticular arthritis and cutaneous papulonodules. Initial clinical diagnosis may be difficult. We describe a 2-year-old girl presenting with pink dermal papules on the forehead, thighs, elbows, knees, and palms of the hands. Based on clinical findings and skin biopsy results, she was initially diagnosed with granuloma annulare. At 5 years of age, she developed arthritis, fatigue, and more widespread skin papules leading to the diagnosis of MRH. To our knowledge, this is the youngest individual with MRH yet described. We outline the timeline and unique features of her case and review the literature pertaining to MRH in children. Although rare, MRH can be permanently debilitating, making prompt diagnosis critical. A standardized approach to investigation and management needs to be developed. |
| Databáze: | OpenAIRE |
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