Unbalanced X;autosome translocation (X;18)(q13;p11) in a case of aggressive natural killer non-Hodgkin lymphoma
| Autor: | Y. Bastion, Pierre Coeur, Sophie Gazzo, Françoise Berger, Pascale Felman, Evelyne Callet-Bauchu, Jacqueline Pagès, Ruth Rimokh |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
congenital hereditary and neonatal diseases and abnormalities Cancer Research X Chromosome Lineage (genetic) Lymphocyte Chromosomal translocation Biology Translocation Genetic Immunophenotyping Natural killer cell immune system diseases X autosome translocation hemic and lymphatic diseases Genetics medicine Humans Cell Lineage Molecular Biology In Situ Hybridization Fluorescence medicine.diagnostic_test Lymphoma Non-Hodgkin Chromosome Xq28 Killer Cells Natural medicine.anatomical_structure Karyotyping Immunology Cancer research Female Chromosomes Human Pair 18 Fluorescence in situ hybridization |
| Zdroj: | Cancer Genetics and Cytogenetics. 98:16-19 |
| ISSN: | 0165-4608 |
| Popis: | Recent evidence has shown that rare cases of aggressive non-Hodgkin lymphomas (NHL) derive from cells belonging to the natural killer (NK) lymphocyte lineage and a new clinico pathologic entity has been proposed. Though well documented in B- and T-cell NHL, chromosome abnormalities are rare findings in NK-NHL and to date, no recurrent cytogenetic abnormality has been described. The present study reports the clinical data, cytogenetic and fluorescence in situ hybridization (FISH) analysis of a new case of typical NK-NHL characterized by a primary unbalanced translocation (X;18) (q13;p11). Recent data of X;autosome translocation in malignant lymphomas have proposed Xp22 and Xq28 as the location of NHL-related oncogenes. According to other published reports on the involvement of the Xq13 region in NHL and particularly in aggressive forms, we hypothesize the existence of additional putative lymphoma-associated oncogenes at the band Xq13. |
| Databáze: | OpenAIRE |
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