Primary leiomyosarcoma of the thyroid gland with prior malignancy and radiotherapy: A case report and review of literature
| Autor: | Milan Bogojevic, Aleksandar Filipovic, Djordjije Krnjevic, Duško Dunđerović, Ljiljana Vuckovic, Jelena Sopta, Snezana Vujosevic |
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| Rok vydání: | 2019 |
| Předmět: |
Leiomyosarcoma
endocrine system medicine.medical_specialty endocrine system diseases medicine.medical_treatment Smooth muscle tumor Malignancy 03 medical and health sciences 0302 clinical medicine stomatognathic system Case report medicine Thyroid Radiotherapy business.industry Thyroidectomy General Medicine medicine.disease 3. Good health body regions Radiation therapy medicine.anatomical_structure 030220 oncology & carcinogenesis Primary Leiomyosarcoma Smooth Muscle Tumor 030211 gastroenterology & hepatology Radiology business |
| Zdroj: | World Journal of Clinical Cases |
| ISSN: | 2307-8960 |
| Popis: | BACKGROUND Leiomyosarcoma (LMS) of the thyroid gland is a rarely presented tumor that offers poor prognosis. To the best of the authors’ knowledge, there currently exist only 28 known cases described in the literature (limited to English). CASE SUMMARY Herein a case is reported of a 60-year-old female patient who had an LMS of the thyroid, which was accompanied by periodic dysphonia and breathing disorder as well as the feeling of pressure in the chest and neck. At the time the disease was diagnosed, no metastases were detected. Prior to the diagnosis, the patient experienced a uterine adenocarcinoma that had been treated by surgical procedure and radiotherapy. For the LMS, a total thyroidectomy was performed, followed by radiotherapy. Since metastases were also discovered in the lungs, sternum, and femur, chemotherapy was administered as well. Immunohistochemically, the tumor cells in the thyroid indicated positively for alpha smooth muscle actin, calponin, and H-caldesmon, but were negative for CD34, p63, estrogen receptor, progesterone receptor, and Epstein-Barr virus. CONCLUSION Although the etiology of the LMS is as of yet unknown, prior malignancy and radiation should be considered as risk factors. |
| Databáze: | OpenAIRE |
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