Inflammatory markers in relation to long-term air pollution
| Autor: | Mostafavi Montazeri, Nahid, Vlaanderen, Jelle, Chadeau-Hyam, Marc, Beelen, Rob, Modig, Lars, Palli, Domenico, Bergdahl, Ingvar A, Vineis, Paolo, Hoek, Gerard, Kyrtopoulos, Soterios Α, Vermeulen, Roel, Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA2, IRAS RATIA-SIB, LS IRAS EEPI ME (Milieu epidemiologie), LS IRAS EEPI GRA (Gezh.risico-analyse) |
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| Přispěvatelé: | Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA2, IRAS RATIA-SIB, LS IRAS EEPI ME (Milieu epidemiologie), LS IRAS EEPI GRA (Gezh.risico-analyse) |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
SYSTEMIC INFLAMMATION BLOOD Air pollution Inflammatory markers Physiology NO2 Systemic inflammation medicine.disease_cause USE REGRESSION-MODELS AREAS PARTICIPANTS Prospective Studies Prospective cohort study lcsh:Environmental sciences General Environmental Science lcsh:GE1-350 Air Pollutants Respiratory disease Confounding Interleukin ESCAPE PROJECT Middle Aged CANCER Italy Cytokines Female Nitrogen Oxides medicine.symptom Life Sciences & Biomedicine Adult Environmental Sciences & Ecology Inflammation CYTOKINE LEVELS MD Multidisciplinary medicine Humans EXPOSURE NOx Aged Sweden Science & Technology business.industry medicine.disease Immunology Linear Models Gene expression business Chronic health effects Environmental Sciences Biomarkers |
| Zdroj: | Environment International, Vol 81, Iss, Pp 1-7 (2015) Environment international, 81, 1. Elsevier Limited |
| ISSN: | 0160-4120 |
| Popis: | Long-term exposure to ambient air pollution can lead to chronic health effects such as cancer, cardiovascular and respiratory disease. Systemic inflammation has been hypothesized as a putative biological mechanism contributing to these adverse health effects. We evaluated the effect of long-term exposure to air pollution on blood markers of systemic inflammation.We measured a panel of 28 inflammatory markers in peripheral blood samples from 587 individuals that were biobanked as part of a prospective study. Participants were from Varese and Turin (Italy) and Umea (Sweden). Long-term air pollution estimates of nitrogen oxides (NOx) were available from the European Study of Cohorts for Air Pollution Effects (ESCAPE). Linear mixed models adjusted for potential confounders were applied to assess the association between NOx and the markers of inflammation.Long-term exposure to NOx was associated with decreased levels of interleukin (IL)-2, IL-8, IL-10 and tumor necrosis factor-α in Italy, but not in Sweden. NOx exposure levels were considerably lower in Sweden than in Italy (Sweden: median (5th, 95th percentiles) 6.65 μg/m3 (4.8, 19.7); Italy: median (5th, 95th percentiles) 94.2 μg/m3 (7.8, 124.5)). Combining data from Italy and Sweden we only observed a significant association between long-term exposure to NOx and decreased levels of circulating IL-8.We observed some indication for perturbations in the inflammatory markers due to long-term exposure to NOx. Effects were stronger in Italy than in Sweden, potentially reflecting the difference in air pollution levels between the two cohorts. Keywords: Air pollution, Inflammatory markers, Gene expression, Chronic health effects |
| Databáze: | OpenAIRE |
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