Light Microscopic Evaluation of Acute and Chronic Hypophyseal Endocrinopathy in a Kaolin-Induced Hydrocephalus Model
| Autor: | Raziye Handan Nurhat, Bizden Sabuncuoğlu, Burak Kazanci, Ferda Topal Çelikkan, Hakan Sabuncuoğlu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Somatotropic cell Adult male medicine.medical_treatment Pituitary Diseases Sham group Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases Internal medicine medicine Animals Kaolin Saline Microscopy business.industry medicine.disease Hydrocephalus Rats Disease Models Animal 030104 developmental biology Endocrinology Acute Disease Chronic Disease Surgery Neurology (clinical) Corticotropic cell Pituitary dysfunction business 030217 neurology & neurosurgery |
| Zdroj: | Turkish neurosurgery. 29(3) |
| ISSN: | 1019-5149 |
| Popis: | AIM To demonstrate progression of acute and chronic endocrinopathies in a kaolin-induced hydrocephalus model using light microscopy. MATERIAL AND METHODS Adult male Sprague-Dawley rats (n = 48) were divided into six groups. Hydrocephalus was induced by intracisternal injection of kaolin solution in the acute and chronic kaolin groups, whereas an identical volume of sterile saline was injected into the sham groups. RESULTS Somatotropic cell concentrations were lower in the kaolin groups compared with their controls, but there was no difference in somatotropic cell concentration between the acute and chronic kaolin groups. Corticotropic cell concentrations were higher in the acute kaolin and sham groups compared with acute controls. Thyrotropic cell numbers were higher in the acute sham and kaolin groups compared with their controls, and although thyrotropic cell concentations were higher in the acute kaolin group than the acute sham group. No differences were observed between the acute and chronic controls and sham and kaolin groups regarding mammotropicand gonadototropic cell concentations. CONCLUSION Somatotropic cells are most affected by hydrocephalus that causes pituitary dysfunction, and this effect was more prominent under acute and chronic phases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|