Contrast harmonic intravascular ultrasound - A feasibility study for vasa vasorum imaging
| Autor: | M.E. Frijlink, David E. Goertz, Nico de Jong, Folkert J. ten Cate, Johannes A. Schaar, Rob Krams, Luc C.A. van Damme, Patrick W. Serruys, Dennie Tempel, Antonius F.W. van der Steen |
|---|---|
| Přispěvatelé: | Cardiology |
| Rok vydání: | 2006 |
| Předmět: |
Novel technique
medicine.medical_specialty media_common.quotation_subject Contrast Media Coronary Artery Disease medicine.disease_cause Intravascular ultrasound medicine Animals Humans Contrast (vision) Radiology Nuclear Medicine and imaging Aorta Abdominal Ultrasonography Interventional media_common Fluorocarbons Microbubbles Neovascularization Pathologic medicine.diagnostic_test Phantoms Imaging business.industry Vasa Vasorum General Medicine Vulnerable plaque medicine.anatomical_structure Vasa vasorum cardiovascular system Harmonic Feasibility Studies Rabbits Venae Cavae Radiology business Biomedical engineering |
| Zdroj: | Investigative Radiology, 41(8), 631-638. Lippincott Williams & Wilkins |
| ISSN: | 0020-9996 |
| Popis: | We sought to investigate feasibility of vasa vasorum imaging using the novel technique of contrast harmonic intravascular ultrasound.Prototype intravascular ultrasound (IVUS) instrumentation was developed for the sensitive detection of micro-bubble contrast agents. The technique, "harmonic" imaging, involves transmitting ultrasound at 20 MHz (fundamental) and detecting contrast signals at 40 MHz (second harmonic). Phantom experiments were conducted to investigate the detection of a small vessel in the wall surrounding a larger vessel. In vivo experiments were conducted in atherosclerotic rabbit abdominal aortas.The phantom experiments showed improved small vessel detection in harmonic mode relative to fundamental mode. For the in vivo experiments, harmonic imaging enabled the visualization of contrast agent outside the aortic lumen through a statistically significant (P0.001) enhancement of image power, consistent with the detection of adventitial microvessels. These microvessels were not detected in fundamental imaging mode.These results indicate the feasibility of contrast harmonic intravascular ultrasound as a new technique for vasa vasorum imaging. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|