Multivariable Analysis of 169 Cases of Advanced Cutaneous Melanoma to Evaluate Antibiotic Exposure as Predictor of Survival to Anti-PD-1 Based Immunotherapies
| Autor: | Sarah L. Mott, Mohammed M. Milhem, Yousef Zakharia, Nicholas Borcherding, Rohan Garje, Adithya Chennamadhavuni, Umang Swami, Aaron D. Bossler |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Oncology medicine.medical_specialty microbiome Ipilimumab Biochemistry Microbiology Article antibiotics Metastasis 03 medical and health sciences 0302 clinical medicine Median follow-up Internal medicine PD-1 medicine melanoma microbiota Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics Proportional hazards model business.industry Melanoma lcsh:RM1-950 medicine.disease lcsh:Therapeutics. Pharmacology 030104 developmental biology Infectious Diseases 030220 oncology & carcinogenesis Cutaneous melanoma Absolute neutrophil count business Brain metastasis medicine.drug |
| Zdroj: | Antibiotics Antibiotics, Vol 9, Iss 740, p 740 (2020) Volume 9 Issue 11 |
| ISSN: | 2079-6382 |
| Popis: | Recently antibiotic exposure has been associated with worse outcomes in patients undergoing treatment with antibodies directed against programmed cell death protein-1 (PD-1). We reviewed data of 1264 patients enrolled at Melanoma Skin and Ocular Tissue Repositories at University of Iowa Hospitals and Clinic. Reviewed data included patient demographics, prior medical history, baseline hematologic and disease parameters and outcomes including progression-free survival (PFS) and overall survival (OS). Cox regression models were used to determine predictive markers. Overall, 169 patients with advanced cutaneous melanoma received anti-PD-1 based therapies. Median follow up was 18.46 (range 0.89 to 62.52) months. On multivariable analysis brain metastasis, higher absolute neutrophil count (ANC) and lower absolute lymphocyte count were associated with poorer PFS while brain and liver metastasis and lower albumin were associated with poorer OS. Prior antibiotics, radiation as well as age, gender, basal metabolic index (BMI), smoking status, BRAF mutation, line of therapy (first or latter), prior treatments (ipilimumab or BRAF inhibitors), hemoglobin, neutrophil-to-lymphocyte ratio, white blood cell, platelet and eosinophil counts were not associated with PFS or OS in multivariable analysis. Contrary to some prior studies BMI, radiation, and antibiotics were not associated with PFS or OS. |
| Databáze: | OpenAIRE |
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