Growth responses to human growth hormone in patients with intrauterine growth retardation
| Autor: | Robert M. Blizzard, Maurice Shaw, Thomas P. Foley, Alice Baghdassarian, Robert G. Thompson, S. Peter Nissley |
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| Rok vydání: | 1974 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Nitrogen Birth weight Physiology Gestational Age Square meter Pregnancy Internal medicine Birth Weight Humans Medicine In patient Child Dwarfism Pituitary Growth Disorders Body surface area Bone Development Growth retardation business.industry Human growth hormone Age Factors Infant Newborn Obstetrics and Gynecology Gestational age General Medicine medicine.disease Endocrinology Skeletal maturation Child Preschool Growth Hormone Pediatrics Perinatology and Child Health Female business |
| Zdroj: | The Journal of Pediatrics. 84:635-641 |
| ISSN: | 0022-3476 |
| Popis: | Twelve patients with low birth weights and/or birth lengths for gestational age were treated with one or more daily doses of human growth hormone (hGH) ranging from 1.0 to 10.2 mg. per square meter of body surface area per day for five to 18 months. Significant delay in skeletal maturation was found in all but one patient. Of the eight patients aged seven years or younger at the time of treatment, the growth rates of five (62.5 per cent) during treatment with hGH were at least twice their pretreatment growth rate; in six (75 per cent) the pretreatment growth rates were exceeded by 3.5 cm. or more per year. Among those patients who received their initial course of hGH therapy in a dose of 2 mg. or more per square meter of body surface area per day, five of eight patients (62.5 per cent) more than doubled their pretreatment growth rates during hGH therapy; seven of eight (88 per cent) increased their pretreatment growth rates by more than 3.5 cm. per year during hGH therapy. In sufficient dose hGH is an effective therapeutic agent in some young patients who have had intrauterine growth retardation. |
| Databáze: | OpenAIRE |
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