Dynamic contrast-enhanced CT for the assessment of tumour response in malignant pleural mesothelioma: a pilot study
| Autor: | Zacariah E. Labby, Eyjolfur Gudmundsson, Buerkley Rose, Christopher M. Straus, Samuel G. Armato, William F. Sensakovic, Hedy L. Kindler, Alexandra R. Cunliffe, Feng Li |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Mesothelioma medicine.medical_specialty Lung Neoplasms Pleural Neoplasms Hemodynamics Antineoplastic Agents Pilot Projects Perfusion scanning Blood volume 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine medicine Humans Radiology Nuclear Medicine and imaging skin and connective tissue diseases Response Evaluation Criteria in Solid Tumors Aged Aged 80 and over Neovascularization Pathologic business.industry Mesothelioma Malignant Ultrasound General Medicine Blood flow Middle Aged medicine.disease Treatment Outcome 030220 oncology & carcinogenesis Cohort Female sense organs Radiology Off Treatment business Tomography Spiral Computed |
| Zdroj: | European Radiology. 29:682-688 |
| ISSN: | 1432-1084 0938-7994 |
| DOI: | 10.1007/s00330-018-5533-9 |
| Popis: | The aim of this pilot study was to investigate the utility of haemodynamic parameters derived from dynamic contrast-enhanced computed tomography (DCE-CT) scans in the assessment of tumour response to treatment in malignant pleural mesothelioma (MPM) patients. The patient cohort included nine patients undergoing chemotherapy and five patients on observation. Each patient underwent two DCE-CT scans separated by approximately 2 months. The DCE-CT parameters of tissue blood flow (BF) and tissue blood volume (BV) were obtained within the dynamically imaged tumour. Mean relative changes in tumour DCE-CT parameters between scans were compared between the on-treatment and on-observation cohorts. DCE-CT parameter changes were correlated with relative change in tumour bulk evaluated according to the modified RECIST protocol. Differing trends in relative change in BF and BV between scans were found between the two patient groups (p = 0.19 and p = 0.06 for BF and BV, respectively). No significant rank correlations were found when comparing relative changes in DCE-CT parameters with relative change in tumour bulk. Differing trends in the relative change of BF and BV between patients on treatment and on observation indicate the potential of DCE-CT for the assessment of pharmacodynamic endpoints with respect to treatment in MPM. A future study with a larger patient cohort and unified treatment regimens should be undertaken to confirm the results of this pilot study. • CT-derived haemodynamic parameters show differing trends between malignant pleural mesothelioma patients on treatment and patients off treatment • Changes in haemodynamic parameters do not correlate with changes in tumour bulk as measured according to the modified RECIST protocol • Differing trends across the two patient groups indicate the potential sensitivity of DCE-CT to assess pharmacodynamic endpoints in the treatment of MPM |
| Databáze: | OpenAIRE |
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