Co-infections associated with human immunodeficiency virus type 1 in pregnant women from southern Brazil: high rate of intraepithelial cervical lesions
| Autor: | Alzira Xavier Garcés, Fabiana Nunes Germano, Michele Tornatore, Elizabeth S. Machado, Ana Maria Barral de Martinez, Mônica Steigleder Bianchi, Marcelo A. Soares, Carla Vitola Gonçalves |
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| Rok vydání: | 2011 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty lcsh:Arctic medicine. Tropical medicine lcsh:RC955-962 Cross-sectional study Birth weight Hepatitis C virus lcsh:QR1-502 HIV Infections medicine.disease_cause lcsh:Microbiology Cohort Studies Pregnancy Prevalence Medicine Humans Pregnancy Complications Infectious Cervical carcinoma STDs Hepatitis B virus Cervical cancer Co-infections co-infections business.industry Obstetrics Coinfection Papillomavirus Infections Infant Newborn Pregnancy Outcome virus diseases medicine.disease Uterine Cervical Dysplasia Cross-Sectional Studies Immunology DNA Viral HIV-1 Syphilis Female cervical carcinoma business Brazil Cohort study |
| Zdroj: | Memórias do Instituto Oswaldo Cruz., Vol 107, Iss 2, Pp 205-210 (2012) Repositório Institucional da FURG (RI FURG) Universidade Federal do Rio Grande (FURG) instacron:FURG Memórias do Instituto Oswaldo Cruz, Volume: 107, Issue: 2, Pages: 205-210, Published: MAR 2012 |
| ISSN: | 1678-8060 |
| Popis: | Human immunodeficiency virus type 1 (HIV-positive) pregnant women require specific prophylactic and therapeutic approaches. The efficacy of established approaches is further challenged by co-infection with other sexually transmitted diseases (STDs). The objective of this study was to determine the prevalence of co-infections in pregnant women infected with different HIV-1 subtypes and to relate these findings, together with additional demographic and clinical parameters, to maternal and infant outcomes. Blood samples from pregnant women were collected and tested for syphilis, hepatitis B virus (HBV) and hepatitis C virus (HCV). Human papillomavirus (HPV) diagnosis was evaluated by the presence of alterations in the cervical epithelium detected through a cytopathological exam. Medical charts provided patient data for the mothers and children. Statistical analyses were conducted with STATA 9.0. We found a prevalence of 10.8% for HCV, 2.3% for chronic HBV, 3.1% for syphilis and 40.8% for HPV. Of those co-infected with HPV, 52.9% presented high-grade intraepithelial lesions or in situ carcinoma. Prematurity, birth weight, Apgar 1' and 5' and Capurro scores were similar between co-infected and non-co-infected women. The presence of other STDs did not impact maternal and concept outcomes. More than half of the patients presenting cervical cytology abnormalities suggestive of HPV had high-grade squamous intraepithelial lesions or cervical cancer, evidencing an alarming rate of these lesions. |
| Databáze: | OpenAIRE |
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