Synthesis of a novel nucleotide unit containing cytosine analog bearing phosphodiester function and formation of silver(I)-mediated DNA duplex

Autor:	A.T.M. Zafrul Azam, Itaru Okamoto, Akira Ono
Rok vydání:	2022
Předmět:	Ions Cytosine Silver Nucleotides Genetics Molecular Medicine General Medicine DNA Biochemistry Organophosphates
Zdroj:	Nucleosides, nucleotidesnucleic acids. 41(11)
ISSN:	1532-2335
Popis:	Novel modified cytosine analogs bearing phosphodiester/thiophosphodiester functionality were synthesized. The interactions between different metal ions and modified cytosine-cytosine base-pairs in DNA duplexes were investigated by UV-melting experiments. The thiophosphodiester modification binds to the Ag(I) ions strongly compared to the phosphodiester counterpart as examined in ESI-MS spectra as well.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b20c01e1e8b43470f3626e2d259b5b45 https://pubmed.ncbi.nlm.nih.gov/35866881 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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