Porous polyurethane film fabricated via the breath figure approach for sustained drug release
| Autor: | Betül Bozdoğan, Gizem Daban, Cem Bayram, Emir Baki Denkbaş |
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| Přispěvatelé: | [Daban, Gizem -- Denkbas, Emir Baki] Hacettepe Univ, Grad Sch Sci & Engn, Bioengn Div, TR-06800 Ankara, Turkey -- [Bayram, Cem] Hacettepe Univ, Adv Technol Applicat & Res Ctr, TR-06800 Ankara, Turkey -- [Bozdogan, Betuel] Aksaray Univ, Fac Sci & Letters, Dept Chem, TR-68100 Aksaray, Turkey -- [Denkbas, Emir Baki] Baskent Univ, Fac Engn, Dept Biomed Engn, TR-06530 Ankara, Turkey, Sabire Yazıcı Fen Edebiyat Fakültesi, Fen Edebiyat Fakültesi |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Popis: | Bozdoğan, Betül ( Aksaray, Yazar ) The breath figure (BF) method is an effective process for fabricating porous polymeric films. In this study, we fabricated porous polymer films from thermoplastic polyurethane (PU) through static BF with CHCl3 as a solvent under 55–80% relative humidity. The porous PU films were prepared within various pore structures and sizes, which were adjustable, depending on the fabrication conditions. The humidity and exposure time were examined as variable parameters affecting the surface morphology, wettability, and cytotoxicity. Atorvastatin calcium, a hyperlipidemic agent, was loaded into the porous films during the casting process, and the drug‐loading and drug‐releasing behaviors of the porous PU membranes were evaluated. Approximately 60–80% of the drug was released in 14 days. The films exhibited sustained drug‐release performances because of the hydrophobicity and nonbiodegradable nature of PU for perivascular drug administration. |
| Databáze: | OpenAIRE |
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